Literature DB >> 15192154

Long-lived Drosophila with overexpressed dFOXO in adult fat body.

Maria E Giannakou1, Martin Goss, Martin A Jünger, Ernst Hafen, Sally J Leevers, Linda Partridge.   

Abstract

Reduced activity of the insulin/insulin-like growth factor signaling (IIS) pathway increases life-span in diverse organisms. We investigated the timing of the effect of reduced IIS on life-span and the role of a potential target tissue, the fat body. We overexpressed dFOXO, a downstream effector of IIS, in the adult Drosophila fat body, which increased life-span and reduced fecundity of females but had no effect on male life-span. The role of FOXO transcription factors and the adipose tissue are therefore evolutionarily conserved in the regulation of aging, and reduction of IIS in the adult is sufficient to mediate its effects on life-span and fecundity.

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Year:  2004        PMID： 15192154     DOI： 10.1126/science.1098219

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  237 in total

1.  Blocking O-linked GlcNAc cycling in Drosophila insulin-producing cells perturbs glucose-insulin homeostasis.

Authors:  Osamu Sekine; Dona C Love; David S Rubenstein; John A Hanover
Journal:  J Biol Chem       Date:  2010-10-06       Impact factor: 5.157

2.  Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan.

Authors:  Rochele Yamamoto; Marc Tatar
Journal:  Aging Cell       Date:  2011-05-27       Impact factor: 9.304

3.  Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.

Authors:  Mette Soerensen; Serena Dato; Qihua Tan; Mikael Thinggaard; Rabea Kleindorp; Marian Beekman; Rune Jacobsen; H Eka D Suchiman; Anton J M de Craen; Rudi G J Westendorp; Stefan Schreiber; Tinna Stevnsner; Vilhelm A Bohr; P Eline Slagboom; Almut Nebel; James W Vaupel; Kaare Christensen; Matt McGue; Lene Christiansen
Journal:  Exp Gerontol       Date:  2012-03-03       Impact factor: 4.032

4.  Drosophila lifespan enhancement by exogenous bacteria.

Authors:  Ted Brummel; Alisa Ching; Laurent Seroude; Anne F Simon; Seymour Benzer
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-20       Impact factor: 11.205

5.  Neuronal expression of Mgat1 rescues the shortened life span of Drosophila Mgat11 null mutants and increases life span.

Authors:  Mohan Sarkar; Konstantin G Iliadi; Peter A Leventis; Harry Schachter; Gabrielle L Boulianne
Journal:  Proc Natl Acad Sci U S A       Date:  2010-05-10       Impact factor: 11.205

6.  Dominant-negative Dmp53 extends life span through the dTOR pathway in D. melanogaster.

Authors:  Johannes H Bauer; Chengyi Chang; Gina Bae; Siti Nur Sarah Morris; Stephen L Helfand
Journal:  Mech Ageing Dev       Date:  2010-02-01       Impact factor: 5.432

7.  Effects of FOXO genotypes on longevity: a biodemographic analysis.

Authors:  Yi Zeng; Lingguo Cheng; Huashuai Chen; Huiqing Cao; Elizabeth R Hauser; Yuzhi Liu; Zhenyu Xiao; Qihua Tan; Xiao-Li Tian; James W Vaupel
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2010-09-30       Impact factor: 6.053

Review 8.  Death and dessert: nutrient signalling pathways and ageing.

Authors:  Nazif Alic; Linda Partridge
Journal:  Curr Opin Cell Biol       Date:  2011-08-09       Impact factor: 8.382

Review 9.  Genetic control of heart function and aging in Drosophila.

Authors:  Karen Ocorr; Laurent Perrin; Hui-Ying Lim; Li Qian; Xiushan Wu; Rolf Bodmer
Journal:  Trends Cardiovasc Med       Date:  2007-07       Impact factor: 6.677

10.  Insulin signaling acts in adult adipocytes via GSK-3β and independently of FOXO to control Drosophila female germline stem cell numbers.

Authors:  Alissa R Armstrong; Daniela Drummond-Barbosa
Journal:  Dev Biol       Date:  2018-05-02       Impact factor: 3.582
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