Literature DB >> 1518905

Physical performance of a positron tomograph for brain imaging with retractable septa.

T J Spinks1, T Jones, D L Bailey, D W Townsend, S Grootoonk, P M Bloomfield, M C Gilardi, M E Casey, B Sipe, J Reed.   

Abstract

Performance characteristics of a new design of positron tomograph with automatically retractable septa for brain imaging have been studied. The device, consisting of block BGO detectors (8 x 8 elements per block), has a ring diameter of 76 cm and an axial FOV of 106.5 mm. The in-plane resolution is on average 5.8 mm and 5.0 mm (FWHM) for stationary and wobble sampling, respectively, over the central 18 cm of the transaxial FOV. Its unique feature is the capability of data acquisition both in the 'conventional' 2D mode (with septa) or 3D mode (septa retracted) where coincidences between any of the 16 detector rings are acquired. When scattered events are subtracted, the efficiency for a 20 cm diameter uniform cylinder increases overall by a factor of 4.8 between 2D (septa extended) and 3D modes. For a 20 cm phantom the trues/singles ratio is higher for 3D than for 2D but for a given unscattered trues rate, the randoms rate in 3D is higher. At 380 keV the scatter fraction within a 20 cm cylinder is 10% (septa extended) and 36% (retracted). In spite of the increase in scatter when septa are retracted, the increased efficiency in the 3D mode of acquisition yields distinct advantages, particularly in the many studies where tracer concentration is low and consequently where dead time and random rates are less important.

Mesh:

Year:  1992        PMID: 1518905     DOI: 10.1088/0031-9155/37/8/002

Source DB:  PubMed          Journal:  Phys Med Biol        ISSN: 0031-9155            Impact factor:   3.609


  27 in total

1.  A default mode of brain function.

Authors:  M E Raichle; A M MacLeod; A Z Snyder; W J Powers; D A Gusnard; G L Shulman
Journal:  Proc Natl Acad Sci U S A       Date:  2001-01-16       Impact factor: 11.205

2.  Where the brain grows old: decline in anterior cingulate and medial prefrontal function with normal aging.

Authors:  José V Pardo; Joel T Lee; Sohail A Sheikh; Christa Surerus-Johnson; Hemant Shah; Kristin R Munch; John V Carlis; Scott M Lewis; Michael A Kuskowski; Maurice W Dysken
Journal:  Neuroimage       Date:  2007-01-25       Impact factor: 6.556

3.  Characterization of extrastriatal D2 in vivo specific binding of [¹⁸F](N-methyl)benperidol using PET.

Authors:  Sarah A Eisenstein; Jon M Koller; Marilyn Piccirillo; Ana Kim; Jo Ann V Antenor-Dorsey; Tom O Videen; Abraham Z Snyder; Morvarid Karimi; Stephen M Moerlein; Kevin J Black; Joel S Perlmutter; Tamara Hershey
Journal:  Synapse       Date:  2012-05-15       Impact factor: 2.562

4.  Validation of the reference tissue model for estimation of dopaminergic D2-like receptor binding with [18F](N-methyl)benperidol in humans.

Authors:  Jo Ann V Antenor-Dorsey; Joanne Markham; Stephen M Moerlein; Tom O Videen; Joel S Perlmutter
Journal:  Nucl Med Biol       Date:  2008-04       Impact factor: 2.408

5.  The temporal dynamics of reading: a PET study.

Authors:  C J Price; K J Friston
Journal:  Proc Biol Sci       Date:  1997-12-22       Impact factor: 5.349

6.  The sensory guidance of movement: a comparison of the cerebellum and basal ganglia.

Authors:  M Jueptner; I H Jenkins; D J Brooks; R S Frackowiak; R E Passingham
Journal:  Exp Brain Res       Date:  1996-12       Impact factor: 1.972

Review 7.  History and future technical innovation in positron emission tomography.

Authors:  Terry Jones; David Townsend
Journal:  J Med Imaging (Bellingham)       Date:  2017-03-31

8.  Regional cerebral blood flow during volitional expiration in man: a comparison with volitional inspiration.

Authors:  S C Ramsay; L Adams; K Murphy; D R Corfield; S Grootoonk; D L Bailey; R S Frackowiak; A Guz
Journal:  J Physiol       Date:  1993-02       Impact factor: 5.182

9.  Functional anatomic studies of memory retrieval for auditory words and visual pictures.

Authors:  R L Buckner; M E Raichle; F M Miezin; S E Petersen
Journal:  J Neurosci       Date:  1996-10-01       Impact factor: 6.167

10.  Radiation dosimetry of N-([11C]methyl)benperidol as determined by whole-body PET imaging of primates.

Authors:  Jo Ann V Antenor-Dorsey; Richard Laforest; Stephen M Moerlein; Tom O Videen; Joel S Perlmutter
Journal:  Eur J Nucl Med Mol Imaging       Date:  2007-12-11       Impact factor: 9.236

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