OBJECTIVE: To evaluate health-related quality of life (HRQOL) in patients with systemic sclerosis (SSc) using the Short Form 36 (SF-36) and to correlate SF-36 scores with clinical and biologic markers. METHODS: The SF-36 was administered to 24 controls and 24 SSc patients. SSc patients also were evaluated for subset (limited SSc [lSSc] and diffuse SSc [dSSc]), age, disease duration, angiotensin-converting enzyme (ACE) levels, autoantibodies, and skin and internal organ involvement. RESULTS: The physical summary score (PSS) was lower in SSc patients than in controls (P < 0.05), whereas the mental summary score (MSS) was higher in dSSc than in lSSc patients (P < 0.05). Five of 8 single SF-36 domain scores were lower in SSc patients than in controls (P < 0.05). Vitality was higher in dSSc than in controls (P < 0.001). In SSc, elder age correlated with lower PSS; low ACE levels and high skin score correlated with higher general mental health and role limitations due to physical problems, respectively (P < 0.05). Patients with heart involvement had higher scores in general health perceptions (P < 0.05). CONCLUSION: The SF-36 shows that HRQOL is impaired in patients with SSc. Higher scores in MSS and vitality in patients with dSSc and correlations of high SF-36 scores with specific organ involvement suggest that SSc patients with severe disease are more able to cope with HRQOL modification.
OBJECTIVE: To evaluate health-related quality of life (HRQOL) in patients with systemic sclerosis (SSc) using the Short Form 36 (SF-36) and to correlate SF-36 scores with clinical and biologic markers. METHODS: The SF-36 was administered to 24 controls and 24 SSc patients. SSc patients also were evaluated for subset (limited SSc [lSSc] and diffuse SSc [dSSc]), age, disease duration, angiotensin-converting enzyme (ACE) levels, autoantibodies, and skin and internal organ involvement. RESULTS: The physical summary score (PSS) was lower in SSc patients than in controls (P < 0.05), whereas the mental summary score (MSS) was higher in dSSc than in lSSc patients (P < 0.05). Five of 8 single SF-36 domain scores were lower in SSc patients than in controls (P < 0.05). Vitality was higher in dSSc than in controls (P < 0.001). In SSc, elder age correlated with lower PSS; low ACE levels and high skin score correlated with higher general mental health and role limitations due to physical problems, respectively (P < 0.05). Patients with heart involvement had higher scores in general health perceptions (P < 0.05). CONCLUSION: The SF-36 shows that HRQOL is impaired in patients with SSc. Higher scores in MSS and vitality in patients with dSSc and correlations of high SF-36 scores with specific organ involvement suggest that SSc patients with severe disease are more able to cope with HRQOL modification.
Authors: S Maddali-Bongi; G Landi; F Galluccio; A Del Rosso; I Miniati; M L Conforti; R Casale; M Matucci-Cerinic Journal: Rheumatol Int Date: 2010-03-18 Impact factor: 2.631
Authors: T A McNearney; H S Sallam; S E Hunnicutt; D Doshi; D E Wollaston; M D Mayes; J D Z Chen Journal: Neurogastroenterol Motil Date: 2009-06-30 Impact factor: 3.598
Authors: S Maddali Bongi; A Del Rosso; I Miniati; F Galluccio; G Landi; G Tai; M Matucci-Cerinic Journal: Rheumatol Int Date: 2011-08-17 Impact factor: 2.631
Authors: L D Carbone; K J Warrington; K D Barrow; M Pugazhenthi; M A Watsky; G Somes; J Ingels; A E Postlethwaite Journal: Clin Exp Immunol Date: 2006-12 Impact factor: 4.330
Authors: Erin L Merz; Vanessa L Malcarne; Scott C Roesch; Deepthi K Nair; Gloria Salazar; Shervin Assassi; Maureen D Mayes Journal: Qual Life Res Date: 2016-07-28 Impact factor: 4.147
Authors: Terry A McNearney; Sonya E Hunnicutt; Michael Fischbach; Alan W Friedman; Martha Aguilar; Chul W Ahn; John D Reveille; Jeffrey R Lisse; Bruce A Baethge; Niti Goel; Maureen D Mayes Journal: J Rheumatol Date: 2009-11-16 Impact factor: 4.666