Literature DB >> 15186836

Study of the green tea polyphenols catechin-3-gallate (CG) and epicatechin-3-gallate (ECG) as proteasome inhibitors.

Sheng Biao Wan1, Di Chen, Q Ping Dou, Tak Hang Chan.   

Abstract

The green tea polyphenol catechin-3-gallate (CG) and epicatechin-3-gallate (ECG) were synthesized enantioselectively via a Sharpless hydroxylation reaction followed by a diastereoselective cyclization. Their potencies to inhibit the proteasome activity were measured. The unnatural enantiomers were found to be equally potent to the natural compounds.

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Year:  2004        PMID： 15186836     DOI： 10.1016/j.bmc.2004.04.033

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  14 in total

1.  Synthesis of (2R, 3R)-epigallocatechin-3-O-(4-hydroxybenzoate), a novel catechin from Cistus salvifolius, and evaluation of its proteasome inhibitory activities.

Authors:  Kumi Osanai; Congde Huo; Kristin R Landis-Piwowar; Q Ping Dou; Tak Hang Chan
Journal:  Tetrahedron       Date:  2007-08-06       Impact factor: 2.457

Review 2.  Green tea polyphenols as proteasome inhibitors: implication in chemoprevention.

Authors:  H Yang; K Landis-Piwowar; T H Chan; Q P Dou
Journal:  Curr Cancer Drug Targets       Date:  2011-03       Impact factor: 3.428

Review 3.  The challenge of developing green tea polyphenols as therapeutic agents.

Authors:  C Huo; S B Wan; W H Lam; L Li; Z Wang; K R Landis-Piwowar; D Chen; Q P Dou; T H Chan
Journal:  Inflammopharmacology       Date:  2008-10       Impact factor: 4.473

4.  Flavonoids as opioid receptor ligands: identification and preliminary structure-activity relationships.

Authors:  Peter L Katavic; Kenneth Lamb; Hernan Navarro; Thomas E Prisinzano
Journal:  J Nat Prod       Date:  2007-08-09       Impact factor: 4.050

5.  Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs.

Authors:  Congde Huo; Huanjie Yang; Qiuzhi Cindy Cui; Q Ping Dou; Tak Hang Chan
Journal:  Bioorg Med Chem       Date:  2009-12-16       Impact factor: 3.641

6.  A para-amino substituent on the D-ring of green tea polyphenol epigallocatechin-3-gallate as a novel proteasome inhibitor and cancer cell apoptosis inducer.

Authors:  Kumi Osanai; Kristin R Landis-Piwowar; Q Ping Dou; Tak Hang Chan
Journal:  Bioorg Med Chem       Date:  2007-05-18       Impact factor: 3.641

Review 7.  Recent advances on tea polyphenols.

Authors:  Jyoti Kanwar; Mujtaba Taskeen; Imthiyaz Mohammad; Congde Huo; Tak Hang Chan; Qing Ping Dou
Journal:  Front Biosci (Elite Ed)       Date:  2012-01-01

8.  Anticancer Effect of a Novel Proteasome Inhibitor, YSY01A, via G2/M Arrest in PC-3M Cells in vitro and in vivo.

Authors:  Mei Zhang; Xia Yuan; Bo Xu; Wei Guo; Fu-Xiang Ran; Run-Tao Li; Jing-Rong Cui
Journal:  J Cancer       Date:  2015-06-11       Impact factor: 4.207

9.  Selective growth inhibition of human malignant melanoma cells by syringic acid-derived proteasome inhibitors.

Authors:  Khaled Y Orabi; Mohamed S Abaza; Khalid A El Sayed; Ahmed Y Elnagar; Rajaa Al-Attiyah; Radhika P Guleri
Journal:  Cancer Cell Int       Date:  2013-08-19       Impact factor: 5.722

10.  Improved synthesis of structural analogues of (-)-epicatechin gallate for modulation of staphylococcal β-lactam resistance.

Authors:  James C Anderson; Helen Grounds; Suzanna Reeves; Peter W Taylor
Journal:  Tetrahedron       Date:  2014-05-27       Impact factor: 2.457
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