Literature DB >> 15186763

LKB1 kinase: master and commander of metabolism and polarity.

James Spicer1, Alan Ashworth.   

Abstract

LKB1, the product of a tumour suppressor gene, is a serine/threonine kinase that coordinates disparate cellular processes. Recent data have revealed novel functions for LKB1, providing new insight into the regulation of cell polarity and energy-generating metabolism.

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Year:  2004        PMID： 15186763     DOI： 10.1016/j.cub.2004.05.012

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  23 in total

1.  Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase.

Authors:  Bin Zheng; Lewis C Cantley
Journal:  Proc Natl Acad Sci U S A       Date:  2007-01-04       Impact factor: 11.205

2.  Genetics and pathology of pancreatic cancer.

Authors:  Jordan M Winter; Anirban Maitra; Charles J Yeo
Journal:  HPB (Oxford)       Date:  2006       Impact factor: 3.647

3.  Akt blocks the tumor suppressor activity of LKB1 by promoting phosphorylation-dependent nuclear retention through 14-3-3 proteins.

Authors:  Ling Liu; Fung-Ming Siu; Chi-Ming Che; Aimin Xu; Yu Wang
Journal:  Am J Transl Res       Date:  2012-04-10       Impact factor: 4.060

4.  Crystallization and preliminary crystallographic analysis of the chimeric protein LKB1-14-3-3ζ.

Authors:  Sheng Ding; Ruiqing Zhou; Yaqin Zhu
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2013-11-29

5.  LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection.

Authors:  Yonghao Cao; Hai Li; Haifeng Liu; Min Zhang; Zichun Hua; Hongbin Ji; Xiaolong Liu
Journal:  EMBO J       Date:  2011-04-12       Impact factor: 11.598

6.  Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling.

Authors:  Yiguo Wang; Dan Du; Longhou Fang; Guang Yang; Chenyi Zhang; Rong Zeng; Axel Ullrich; Friedrich Lottspeich; Zhengjun Chen
Journal:  EMBO J       Date:  2006-10-19       Impact factor: 11.598

Review 7.  The lentiginoses: cutaneous markers of systemic disease and a window to new aspects of tumourigenesis.

Authors:  A J Bauer; C A Stratakis
Journal:  J Med Genet       Date:  2005-06-15       Impact factor: 6.318

8.  No association between promoter polymorphism of STK11 gene and lung cancer risk in the Korean population.

Authors:  Jae Sook Sung; Young Mi Whang; Kyong Hwa Park; Jeong-Seon Ryu; Jong Gwon Choi; Jae Hong Seo; Sang Won Shin; Jun Suk Kim; Yeul Hong Kim
Journal:  Cancer Res Treat       Date:  2009-12-31       Impact factor: 4.679

9.  Beta-arrestin inhibits CAMKKbeta-dependent AMPK activation downstream of protease-activated-receptor-2.

Authors:  Ping Wang; Yong Jiang; Yinsheng Wang; John Y Shyy; Kathryn A DeFea
Journal:  BMC Biochem       Date:  2010-09-21       Impact factor: 4.059

10.  Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion.

Authors:  Juan Li; Jie Liu; Pingping Li; Xiaona Mao; Wenjie Li; Jin Yang; Peijun Liu
Journal:  J Exp Clin Cancer Res       Date:  2014-09-02
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