Scott B Patten1, Corrado Barbui. 1. Department of Community Health Sciences, Faculty of Medicine, University of Calgary, Calgary, AB, Canada. patten@ucalgary.ca
Abstract
BACKGROUND: Certain medications may contribute to the etiology of depressive symptoms and disorders. Research in this area, however, has been hampered by methodological and conceptual problems. This review had two objectives: to identify evidence linking medical drugs to depressive symptoms and disorders, and to summarize this evidence in a clinically meaningful way. METHODS: Electronic literature searches were performed and studies were reviewed with reference to critical methodological features. RESULTS: No medications causing the typical major depressive syndrome were identified. Evidence was found linking corticosteroids, interferon-alpha, interleukin-2, gonadotropin-releasing hormone agonists, mefloquine, progestin-releasing implanted contraceptives and propranolol to the etiology of atypical depressive syndromes. CONCLUSIONS: A small number of drugs have been shown capable of inducing depressive symptoms. Drug-induced depression appears to differ symptomatically from classical major depression. Copyright 2004 S. Karger AG, Basel
BACKGROUND: Certain medications may contribute to the etiology of depressive symptoms and disorders. Research in this area, however, has been hampered by methodological and conceptual problems. This review had two objectives: to identify evidence linking medical drugs to depressive symptoms and disorders, and to summarize this evidence in a clinically meaningful way. METHODS: Electronic literature searches were performed and studies were reviewed with reference to critical methodological features. RESULTS: No medications causing the typical major depressive syndrome were identified. Evidence was found linking corticosteroids, interferon-alpha, interleukin-2, gonadotropin-releasing hormone agonists, mefloquine, progestin-releasing implanted contraceptives and propranolol to the etiology of atypical depressive syndromes. CONCLUSIONS: A small number of drugs have been shown capable of inducing depressive symptoms. Drug-induced depression appears to differ symptomatically from classical major depression. Copyright 2004 S. Karger AG, Basel
Authors: Susan E Ramsey; Patricia A Engler; Michael D Stein; Richard A Brown; Patricia Cioe; Christopher W Kahler; Kittichai Promrat; Jennifer Rose; Jennifer Anthony; David A Solomon Journal: J Addict Res Ther Date: 2011-05-13
Authors: Christopher M Celano; Oliver Freudenreich; Carlos Fernandez-Robles; Theodore A Stern; Mario A Caro; Jeff C Huffman Journal: Dialogues Clin Neurosci Date: 2011 Impact factor: 5.986