Kristina Johnell1, Johan Fastbom. 1. Aging Research Center, Karolinska Institutet, Gävlegatan 16, 11330 Stockholm, Sweden. Kristina.Johnell@ki.se
Abstract
PURPOSE: To investigate whether cardiovascular drug classes and specific beta-blockers are associated with antidepressant drug use in a large study population of older people. METHODS: We analyzed data from the Swedish Prescribed Drug Register from October-December 2005 for people aged 75 years and older (n = 732,230). Logistic regression analysis was used to study the association between the cardiovascular drugs and antidepressants, after adjustment for age, sex, and number of other dispensed drugs. RESULTS: All the cardiovascular drug classes were negatively or not associated with use of any antidepressant, non-selective monoamine reuptake inhibitors, and SSRIs, after adjustment for age, sex, and number of other dispensed drugs. However, propranolol was associated with an increased use of any antidepressant, non-selective monoamine reuptake inhibitors, and SSRIs, after adjustment for age, sex, and number of other dispensed drugs. Atenolol was positively associated with non-selective monoamine reuptake inhibitors, although to a lesser extent than propranolol. CONCLUSIONS: None of the cardiovascular drug classes were associated with increased antidepressant drug use, after adjustment for age, sex, and use of other drugs. However, when focusing specifically on beta-blockers, our results indicate that propranolol may be the beta-blocker most closely associated with use of antidepressants in the elderly.
PURPOSE: To investigate whether cardiovascular drug classes and specific beta-blockers are associated with antidepressant drug use in a large study population of older people. METHODS: We analyzed data from the Swedish Prescribed Drug Register from October-December 2005 for people aged 75 years and older (n = 732,230). Logistic regression analysis was used to study the association between the cardiovascular drugs and antidepressants, after adjustment for age, sex, and number of other dispensed drugs. RESULTS: All the cardiovascular drug classes were negatively or not associated with use of any antidepressant, non-selective monoamine reuptake inhibitors, and SSRIs, after adjustment for age, sex, and number of other dispensed drugs. However, propranolol was associated with an increased use of any antidepressant, non-selective monoamine reuptake inhibitors, and SSRIs, after adjustment for age, sex, and number of other dispensed drugs. Atenolol was positively associated with non-selective monoamine reuptake inhibitors, although to a lesser extent than propranolol. CONCLUSIONS: None of the cardiovascular drug classes were associated with increased antidepressant drug use, after adjustment for age, sex, and use of other drugs. However, when focusing specifically on beta-blockers, our results indicate that propranolol may be the beta-blocker most closely associated with use of antidepressants in the elderly.
Authors: Joost P van Melle; Daniëlle E P Verbeek; Maarten P van den Berg; Johan Ormel; Marcel R van der Linde; Peter de Jonge Journal: J Am Coll Cardiol Date: 2006-11-09 Impact factor: 24.094
Authors: Joseph V Agostini; Mary E Tinetti; Ling Han; Peter Peduzzi; Joanne M Foody; John Concato Journal: J Gen Intern Med Date: 2007-09-25 Impact factor: 5.128