Literature DB >> 15184632

Improved motor skill acquisition after selective stimulation of central norepinephrine.

Christian Plewnia1, Julia Hoppe, Leonardo G Cohen, Christian Gerloff.   

Abstract

It has been proposed that the beneficial effects of training on motor function can be enhanced by stimulation of alpha-adrenergic mechanisms. Consistent with this view, a single oral dose of the selective norepinephrine reuptake inhibitor reboxetine was found to enhance motor skill acquisition (rapid elbow flexion) and corticomotor excitability tested with transcranial magnetic stimulation in the absence of effects on basal motor performance. Therefore, alpha-adrenergic mechanisms could possibly be manipulated to magnify training effects in neurorehabilitation.

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Year:  2004        PMID： 15184632     DOI： 10.1212/01.wnl.0000128041.92710.17

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  17 in total

Review 1.  Clinical practice. Rehabilitation after stroke.

Authors:  Bruce H Dobkin
Journal:  N Engl J Med       Date:  2005-04-21       Impact factor: 91.245

2.  Noradrenergic modulation of activity in a vocal control nucleus in vitro.

Authors:  Michele M Solis; David J Perkel
Journal:  J Neurophysiol       Date:  2005-12-21       Impact factor: 2.714

3.  No effects of enhanced central norepinephrine on finger-sequence learning and attention.

Authors:  Christian Plewnia; Julia Hoppe; Christian Gerloff
Journal:  Psychopharmacology (Berl)       Date:  2006-06-10       Impact factor: 4.530

4.  Reboxetine improves motor function in chronic stroke. A pilot study.

Authors:  Simone Zittel; Cornelius Weiller; Joachim Liepert
Journal:  J Neurol       Date:  2007-02-03       Impact factor: 4.849

5.  Acute and chronic effects of noradrenergic enhancement on transcranial direct current stimulation-induced neuroplasticity in humans.

Authors:  Hsiao-I Kuo; Walter Paulus; Giorgi Batsikadze; Asif Jamil; Min-Fang Kuo; Michael A Nitsche
Journal:  J Physiol       Date:  2016-12-07       Impact factor: 5.182

Review 6.  Noradrenergic modulation of working memory and emotional memory in humans.

Authors:  Samuel R Chamberlain; Ulrich Müller; Andrew D Blackwell; Trevor W Robbins; Barbara J Sahakian
Journal:  Psychopharmacology (Berl)       Date:  2006-04-27       Impact factor: 4.530

7.  Visual Attention Affects the Amplitude of the Transcranial Magnetic Stimulation-associated Motor-evoked Potential: A Preliminary Study With Clinical Utility.

Authors:  Spencer J Bell; Abigail Lauer; Daniel H Lench; Colleen A Hanlon
Journal:  J Psychiatr Pract       Date:  2018-07       Impact factor: 1.325

Review 8.  Neurochemical changes underpinning the development of adjunct therapies in recovery after stroke: A role for GABA?

Authors:  Ainslie Johnstone; Jacob M Levenstein; Emily L Hinson; Charlotte J Stagg
Journal:  J Cereb Blood Flow Metab       Date:  2017-09-20       Impact factor: 6.200

9.  Chronic dose effects of reboxetine on motor skill acquisition and cortical excitability.

Authors:  R Lange; C Weiller; J Liepert
Journal:  J Neural Transm (Vienna)       Date:  2007-03-31       Impact factor: 3.575

10.  Whole body heat stress increases motor cortical excitability and skill acquisition in humans.

Authors:  Andrew E Littmann; Richard K Shields
Journal:  Clin Neurophysiol       Date:  2015-11-10       Impact factor: 3.708
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