| Literature DB >> 15183541 |
Yetrib Hathout1, Marion L Gehrmann, Andrei Chertov, Catherine Fenselau.
Abstract
The adriamycin resistant breast cancer cell line (MCF-7/ADR) is a subject of ongoing debate concerning its origin and or source. Previous studies in our laboratory showed that MCF-7/ADR has a unique cytosolic protein expression pattern when compared to that of the parental MCF-7 cell line and other drug resistant MCF-7 cell lines. Protein expression patterns obtained using two-dimensional gel electrophoresis and mass spectrometry indicated that this MCF-7/ADR cell line shares some similarities with the metastatic breast cancer cell lines MDA-MB. Further comparisons with available two-dimensional gel electrophoresis maps in the literature indicate that MCF-7/ADR has a protein expression signature even closer to of the ductal infiltrating breast carcinoma cell line 8701. These observations suggest that MCF-7/ADR cells might have originated in a selection of ductal infiltrating carcinoma cells, which were present among the original MCF-7 cell population. These ductal infiltrating carcinoma cells may possess an intrinsic adriamycin resistance phenotype. Copyright 2004 Elsevier Ireland Ltd.Entities:
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Year: 2004 PMID： 15183541 DOI： 10.1016/j.canlet.2004.01.019
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679