Literature DB >> 15181902

Syphilis.

R W Peeling1, D C W Mabey.   

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Year:  2004        PMID: 15181902      PMCID: PMC7097304          DOI: 10.1038/nrmicro911

Source DB:  PubMed          Journal:  Nat Rev Microbiol        ISSN: 1740-1526            Impact factor:   60.633


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New SARS alert

The Chinese Ministry of Health reported several new cases of possible SARS in Beijing and in a province in east-central China in April. Four cases are suspected and five have been confirmed, including one fatality. All cases are believed to be linked to lapses in safety procedures in the National Institute of Virology in Beijing, where two of the infected individuals worked; the Institute has been temporarily closed, and all staff are in isolation. So far, there is no evidence of widespread transmission in the community — all cases are linked to chains of transmission based on close personal contact with an identified case. WHO/CDC

Drug-resistant gonorrhoea

Preliminary data showing that the number of cases of drug-resistant gonorrhoea in the United States increased significantly in 2003, particularly among men who have sex with men, have prompted the CDC to issue a recommendation that fluoroquinolones are no longer used as first-line therapy for this patient group. The CDC Gonococcal Surveillance Unit found that the occurrence of fluoroquinolone-resistant Neisseria gonorrhoeae had increased threefold between 2002 and 2003 in men who have sex with men. Alternative treatment options for some patients, depending on their case history, include ceftriaxone or spectinomycin, both of which must be administered by injection and are therefore more expensive. CDC

Africa Malaria Day

This year's Africa Malaria Day on April 25th focused on children, with the slogan 'Children for Children to Roll Back Malaria', and the campaign hoped to raise awareness in children and allow children and young adults to become advocates for malaria control in malaria-endemic countries. The day marked the fourth anniversary of the Abuja Declaration, a commitment by African leaders and governments to halve mortality from malaria by 2010, and Dr Ebrahim Malik Samba, the WHO's Regional Director for Africa, issued a statement calling on WHO Member States to intensify their efforts to reach the Abuja goal. The WHO Director also spoke to highlight the WHO's position that malaria-endemic countries should adopt artemisinin-based combination therapies. WHO

Focus on measles

The number of deaths from measles in the period 1999–2002 decreased by 30% worldwide, according to a recent announcement from UNICEF and the WHO. The goal of halving global measles mortality by 2005 could therefore be achievable. It is believed that a new WHO/UNICEF strategy — 80% routine immunization coverage combined with supplemental immunization activities in high-burden countries — has contributed to the reduction. The good news coincided with Vaccination Week in the Americas, when millions of people were expected to be immunized. However, measles is still a cause for concern in Japan, where the rates of measles mortality are higher than in other developed countries. Additionally, a small outbreak in America received press attention when it was traced to children who had been adopted from an orphanage in China. WHO/UNICEF/CDC
  11 in total

1.  Evaluation of LIAISON Treponema Screen, a novel recombinant antigen-based chemiluminescence immunoassay for laboratory diagnosis of syphilis.

Authors:  Antonella Marangoni; Vittorio Sambri; Silvia Accardo; Francesca Cavrini; Antonietta D'Antuono; Alessandra Moroni; Elisa Storni; Roberto Cevenini
Journal:  Clin Diagn Lab Immunol       Date:  2005-10

2.  Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidum.

Authors:  Derek Parsonage; Daniel C Desrosiers; Karsten R O Hazlett; Yongcheng Sun; Kimberly J Nelson; David L Cox; Justin D Radolf; Leslie B Poole
Journal:  Proc Natl Acad Sci U S A       Date:  2010-03-19       Impact factor: 11.205

3.  Laboratory diagnosis of syphilis with automated immunoassays.

Authors:  Antonella Marangoni; Alessandra Moroni; Silvia Accardo; Roberto Cevenini
Journal:  J Clin Lab Anal       Date:  2009       Impact factor: 2.352

4.  Reactivity of antibodies from syphilis patients to a protein array representing the Treponema pallidum proteome.

Authors:  Mary Beth Brinkman; Matthew McKevitt; Melanie McLoughlin; Carla Perez; Jerrilyn Howell; George M Weinstock; Steven J Norris; Timothy Palzkill
Journal:  J Clin Microbiol       Date:  2006-03       Impact factor: 5.948

5.  Evaluation of the BioPlex 2200 syphilis system as a first-line method of reverse-sequence screening for syphilis diagnosis.

Authors:  Antonella Marangoni; Paola Nardini; Claudio Foschi; Alessandra Moroni; Antonietta D'Antuono; Letizia Bacchi Reggiani; Roberto Cevenini
Journal:  Clin Vaccine Immunol       Date:  2013-05-22

Review 6.  Syphilitic Gummata in the Central Nervous System: A Narrative Review and Case Report about a Noteworthy Clinical Manifestation.

Authors:  Lennart Barthel; Susann Hetze; Sarah Teuber-Hanselmann; Valérie Chapot; Ulrich Sure
Journal:  Microorganisms       Date:  2021-04-23

Review 7.  Poor Reporting of Outcomes Beyond Accuracy in Point-of-Care Tests for Syphilis: A Call for a Framework.

Authors:  Yalda Jafari; Mira Johri; Lawrence Joseph; Caroline Vadnais; Nitika Pant Pai
Journal:  AIDS Res Treat       Date:  2014-03-27

Review 8.  Efforts in blood safety: Integrated approach for serological diagnosis of syphilis.

Authors:  Linda Sommese; Maria Rosaria De Pascale; Maria Capuano; Claudio Napoli
Journal:  Asian J Transfus Sci       Date:  2016 Jan-Jun

9.  Epidemic of venereal treponematosis in wild monkeys: a paradigm for syphilis origin.

Authors:  O Mediannikov; F Fenollar; B Davoust; N Amanzougaghene; H Lepidi; J-P Arzouni; G Diatta; C Sokhna; J Delerce; A Levasseur; D Raoult
Journal:  New Microbes New Infect       Date:  2020-03-26

10.  The binary protein interactome of Treponema pallidum--the syphilis spirochete.

Authors:  Björn Titz; Seesandra V Rajagopala; Johannes Goll; Roman Häuser; Matthew T McKevitt; Timothy Palzkill; Peter Uetz
Journal:  PLoS One       Date:  2008-05-28       Impact factor: 3.240

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