Literature DB >> 15177571

Deletion of multimerin-1 in alpha-synuclein-deficient mice.

Christian G Specht1, Ralf Schoepfer.   

Abstract

A deletion of the murine Snca gene has been discovered in C57BL/6JOlaHsd, a population of the inbred strain C57BL/6J. We now characterize the exact nature of this deletion, Del(6)Snca1Slab. Detailed mapping and sequencing of the breakpoint revealed the absence of 365 kb, encompassing the Mmrn1 gene in addition to Snca. Despite the lack of alpha-synuclein and multimerin-1 C57BL/6JOlaHsd animals do not display obvious phenotypes. Sequence comparisons revealed that the chromosomal organization of Sncg and Mmrn2 is highly reminiscent of the region containing Snca and Mmrn1, suggesting a duplication event of a cluster of apparently unrelated genes during evolution.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15177571     DOI： 10.1016/j.ygeno.2003.12.014

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  15 in total

1.  Homeostatic plasticity mechanisms are required for juvenile, but not adult, ocular dominance plasticity.

Authors:  Adam Ranson; Claire E J Cheetham; Kevin Fox; Frank Sengpiel
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-09       Impact factor: 11.205

2.  Alpha-synuclein deletion decreases motor impulsivity but does not affect risky decision making in a mouse Gambling Task.

Authors:  Yolanda Peña-Oliver; Sandra Sanchez-Roige; David N Stephens; Tamzin L Ripley
Journal:  Psychopharmacology (Berl)       Date:  2014-01-09       Impact factor: 4.530

3.  Novel insights into the genetic background of genetically modified mice.

Authors:  Peter Dobrowolski; Melina Fischer; Ronald Naumann
Journal:  Transgenic Res       Date:  2018-04-16       Impact factor: 2.788

4.  Unexpected rescue of alpha-synuclein and multimerin1 deletion in C57BL/6JOlaHsd mice by beta-adducin knockout.

Authors:  Srećko Gajović; Dinko Mitrecić; Lana Augustincić; Alessandra Iaconcig; Andrés F Muro
Journal:  Transgenic Res       Date:  2006-04       Impact factor: 2.788

5.  Lack of involvement of alpha-synuclein in unconditioned anxiety in mice.

Authors:  Yolanda Peña-Oliver; Vladimir L Buchman; David N Stephens
Journal:  Behav Brain Res       Date:  2010-02-04       Impact factor: 3.332

6.  A spontaneous deletion of α-synuclein is associated with an increase in CB1 mRNA transcript and receptor expression in the hippocampus and amygdala: effects on alcohol consumption.

Authors:  Alejandro López-Jiménez; Nicole A R Walter; Elena Giné; Ángel Santos; Victor Echeverry-Alzate; Kora-Mareen Bühler; Pedro Olmos; Stéphanie Giezendanner; Rosario Moratalla; Lluis Montoliu; Kari J Buck; Jose Antonio López-Moreno
Journal:  Synapse       Date:  2013-03-20       Impact factor: 2.562

7.  Genomic investigation of alpha-synuclein multiplication and parkinsonism.

Authors:  Owen A Ross; Adam T Braithwaite; Lisa M Skipper; Jennifer Kachergus; Mary M Hulihan; Frank A Middleton; Kenya Nishioka; Julia Fuchs; Thomas Gasser; Demetrius M Maraganore; Charles H Adler; Lydie Larvor; Marie-Christine Chartier-Harlin; Christer Nilsson; J William Langston; Katrina Gwinn; Nobutaka Hattori; Matthew J Farrer
Journal:  Ann Neurol       Date:  2008-06       Impact factor: 10.422

8.  An exome study of Parkinson's disease in Sardinia, a Mediterranean genetic isolate.

Authors:  Marialuisa Quadri; Xu Yang; Giovanni Cossu; Simone Olgiati; Valeria M Saddi; Guido J Breedveld; Limei Ouyang; Jingchu Hu; Na Xu; Josja Graafland; Valeria Ricchi; Daniela Murgia; Leonor Correia Guedes; Claudio Mariani; Maria J Marti; Patrizia Tarantino; Rosanna Asselta; Francesc Valldeoriola; Monica Gagliardi; Gianni Pezzoli; Mario Ezquerra; Aldo Quattrone; Joaquim Ferreira; Grazia Annesi; Stefano Goldwurm; Eduardo Tolosa; Ben A Oostra; Maurizio Melis; Jun Wang; Vincenzo Bonifati
Journal:  Neurogenetics       Date:  2014-10-08       Impact factor: 2.660

9.  Substrains matter in phenotyping of C57BL/6 mice.

Authors:  Kazuyuki Mekada; Atsushi Yoshiki
Journal:  Exp Anim       Date:  2021-01-14

10.  Deletion of alpha-synuclein decreases impulsivity in mice.

Authors:  Y Peña-Oliver; V L Buchman; J W Dalley; T W Robbins; G Schumann; T L Ripley; S L King; D N Stephens
Journal:  Genes Brain Behav       Date:  2011-12-29       Impact factor: 3.449
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.