| Literature DB >> 15177472 |
Tatiana Santana Ribeiro1, Leonardo Freire-de-Lima, José Osvaldo Previato, Lucia Mendonça-Previato, Norton Heise, Marco Edilson Freire de Lima.
Abstract
We describe herein an evaluation of trypanocidal effects of the natural alkaloid piperine and twelve synthetic derivatives against epimastigote and amastigote forms of the protozoan parasite Trypanosoma cruzi, the causative agent of the incurable human disease, Chagas' disease. The results obtained point to piperine as a suitable template for the development of new drugs with trypanocidal activity.Entities:
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Year: 2004 PMID： 15177472 DOI： 10.1016/j.bmcl.2004.04.019
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823