Literature DB >> 15174970

Hydrogels for oral delivery of therapeutic proteins.

Nicholas A Peppas1, Kristy M Wood, James O Blanchette.   

Abstract

In recent years there has been significant new interest in the development of transmucosal (mostly oral) pharmaceutical formulations for the delivery of therapeutic proteins. Emphasis has been given to the molecular design of new carriers for the delivery of insulin, calcitonin and various types of interferons for the treatment of diabetes, osteoporosis, multiple sclerosis and cancer. Most popular carriers include advanced designs of swollen hydrogels prepared from neutral or intelligent polymeric networks. In this review, the most successful of such systems are presented and their promise in the field described.

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Year:  2004        PMID： 15174970     DOI： 10.1517/14712598.4.6.881

Source DB:  PubMed          Journal:  Expert Opin Biol Ther        ISSN： 1471-2598            Impact factor:   4.388


  34 in total

Review 1.  Microfabrication technologies for oral drug delivery.

Authors:  Shilpa Sant; Sarah L Tao; Omar Z Fisher; Qiaobing Xu; Nicholas A Peppas; Ali Khademhosseini
Journal:  Adv Drug Deliv Rev       Date:  2011-12-04       Impact factor: 15.470

Review 2.  Hydrogels and scaffolds for immunomodulation.

Authors:  Ankur Singh; Nicholas A Peppas
Journal:  Adv Mater       Date:  2014-08-25       Impact factor: 30.849

3.  Colloidal microgels in drug delivery applications.

Authors:  Serguei V Vinogradov
Journal:  Curr Pharm Des       Date:  2006       Impact factor: 3.116

4.  New cyclodextrin hydrogels cross-linked with diglycidylethers with a high drug loading and controlled release ability.

Authors:  Carmen Rodriguez-Tenreiro; Carmen Alvarez-Lorenzo; Ana Rodriguez-Perez; Angel Concheiro; Juan J Torres-Labandeira
Journal:  Pharm Res       Date:  2006-12-07       Impact factor: 4.200

5.  Investigations on the physical structure and the mechanism of drug release from an enteric matrix microspheres with a near-zero-order release kinetics using SEM and quantitative FTIR.

Authors:  Wasfy M Obeidat; Safwan M Obeidat; Nizar M Alzoubi
Journal:  AAPS PharmSciTech       Date:  2009-05-15       Impact factor: 3.246

Review 6.  Novel platforms for oral drug delivery.

Authors:  P Colombo; F Sonvico; G Colombo; R Bettini
Journal:  Pharm Res       Date:  2009-01-09       Impact factor: 4.200

Review 7.  Combinatorial approaches in post-polymerization modification for rational development of therapeutic delivery systems.

Authors:  Yuanbo Zhong; Brian J Zeberl; Xu Wang; Juntao Luo
Journal:  Acta Biomater       Date:  2018-04-12       Impact factor: 8.947

8.  Microfabrication of an asymmetric, multi-layered microdevice for controlled release of orally delivered therapeutics.

Authors:  Kristy M Ainslie; Casey M Kraning; Tejal A Desai
Journal:  Lab Chip       Date:  2008-05-16       Impact factor: 6.799

9.  Synthesis and characterization of polymer nanocarriers for the targeted delivery of therapeutic enzymes.

Authors:  Eric Simone; Thomas Dziubla; Vladimir Shuvaev; Vladimir R Muzykantov
Journal:  Methods Mol Biol       Date:  2010

10.  Sustained release tablets containing soluble polymethacrylates: comparison with tableted polymethacrylate IPEC polymers.

Authors:  Wasfy M Obeidat; Alaa H Abuznait; Al-Sayed A Sallam
Journal:  AAPS PharmSciTech       Date:  2010-01-07       Impact factor: 3.246
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