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Literature DB >> 15166176

Natural selection affects frequencies of AG and GT dinucleotides at the 5' and 3' ends of exons.

Abstract

GT and AG, located at the 5' and 3' ends of introns, are important for correct splicing. It is anticipated that natural selection decreases frequency of AG and GT near the 5' and 3' ends of exons, preventing appearance of cryptic splicing sites. The data presented in this article support the expectation.

Entities: Chemical

Mesh：

Substances：
Codon

Year: 2004 PMID： 15166176 PMCID： PMC1470862 DOI： 10.1534/genetics.167.1.543

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

9 in total

1. EID: the Exon-Intron Database-an exhaustive database of protein-coding intron-containing genes.

Authors: S Saxonov; I Daizadeh; A Fedorov; W Gilbert
Journal: Nucleic Acids Res Date: 2000-01-01 Impact factor: 16.971

Review 2. When the message goes awry: disease-producing mutations that influence mRNA content and performance.

Authors: J T Mendell; H C Dietz
Journal: Cell Date: 2001-11-16 Impact factor: 41.582

Review 3. Splicing regulation as a potential genetic modifier.

Authors: Malka Nissim-Rafinia; Batsheva Kerem
Journal: Trends Genet Date: 2002-03 Impact factor: 11.639

4. Predictive identification of exonic splicing enhancers in human genes.

Authors: William G Fairbrother; Ru-Fang Yeh; Phillip A Sharp; Christopher B Burge
Journal: Science Date: 2002-07-11 Impact factor: 47.728

Review 5. Alternative pre-mRNA splicing and proteome expansion in metazoans.

Authors: Tom Maniatis; Bosiljka Tasic
Journal: Nature Date: 2002-07-11 Impact factor: 49.962

6. What drives codon choices in human genes?

Authors: S Karlin; J Mrázek
Journal: J Mol Biol Date: 1996-10-04 Impact factor: 5.469

7. Codon usage bias covaries with expression breadth and the rate of synonymous evolution in humans, but this is not evidence for selection.

Authors: A O Urrutia; L D Hurst
Journal: Genetics Date: 2001-11 Impact factor: 4.562

8. Analysis of canonical and non-canonical splice sites in mammalian genomes.

Authors: M Burset; I A Seledtsov; V V Solovyev
Journal: Nucleic Acids Res Date: 2000-11-01 Impact factor: 16.971

9. The covariation between TpA deficiency, CpG deficiency, and G+C content of human isochores is due to a mathematical artifact.

Authors: L Duret; N Galtier
Journal: Mol Biol Evol Date: 2000-11 Impact factor: 16.240

9 in total

15 in total

Natural selection affects frequencies of AG and GT dinucleotides at the 5' and 3' ends of exons.

1. EID: the Exon-Intron Database-an exhaustive database of protein-coding intron-containing genes.

Review 2. When the message goes awry: disease-producing mutations that influence mRNA content and performance.

Review 3. Splicing regulation as a potential genetic modifier.

4. Predictive identification of exonic splicing enhancers in human genes.

Review 5. Alternative pre-mRNA splicing and proteome expansion in metazoans.

6. What drives codon choices in human genes?

7. Codon usage bias covaries with expression breadth and the rate of synonymous evolution in humans, but this is not evidence for selection.

8. Analysis of canonical and non-canonical splice sites in mammalian genomes.

9. The covariation between TpA deficiency, CpG deficiency, and G+C content of human isochores is due to a mathematical artifact.

1. Can codon usage bias explain intron phase distributions and exon symmetry?

2. Limitations of the 'ambush hypothesis' at the single-gene scale: what codon biases are to blame?

Review 3. In Silico Functional Annotation of Genomic Variation.

Review 4. Synonymous but not the same: the causes and consequences of codon bias.

5. Preliminary assessment of the impact of microRNA-mediated regulation on coding sequence evolution in mammals.

6. Determination of the consequences of VHL mutations on VHL transcripts in renal cell carcinoma.

7. Biased exon/intron distribution of cryptic and de novo 3' splice sites.

8. Splicing and the evolution of proteins in mammals.

9. Translational signatures and mRNA levels are highly correlated in human stably expressed genes.

10. Selection against tandem splice sites affecting structured protein regions.