Literature DB >> 15164073

Oncogenomics and the development of new cancer therapies.

Robert L Strausberg1, Andrew J G Simpson, Lloyd J Old, Gregory J Riggins.   

Abstract

Scientists have sequenced the human genome and identified most of its genes. Now it is time to use these genomic data, and the high-throughput technology developed to generate them, to tackle major health problems such as cancer. To accelerate our understanding of this disease and to produce targeted therapies, further basic mutational and functional genomic information is required. A systematic and coordinated approach, with the results freely available, should speed up progress. This will best be accomplished through an international academic and pharmaceutical oncogenomics initiative.

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Year:  2004        PMID: 15164073     DOI: 10.1038/nature02627

Source DB:  PubMed          Journal:  Nature        ISSN: 0028-0836            Impact factor:   49.962


  21 in total

1.  Incorporating the human gene annotations in different databases significantly improved transcriptomic and genetic analyses.

Authors:  Geng Chen; Charles Wang; Leming Shi; Xiongfei Qu; Jiwei Chen; Jianmin Yang; Caiping Shi; Long Chen; Peiying Zhou; Baitang Ning; Weida Tong; Tieliu Shi
Journal:  RNA       Date:  2013-02-19       Impact factor: 4.942

2.  Design and structure activity relationship of tumor-homing histone deacetylase inhibitors conjugated to folic and pteroic acids.

Authors:  Quaovi H Sodji; James R Kornacki; John F McDonald; Milan Mrksich; Adegboyega K Oyelere
Journal:  Eur J Med Chem       Date:  2015-04-08       Impact factor: 6.514

3.  Discovery of a new biomarker for gastroenterological cancers.

Authors:  Hiroyuki Aburatani
Journal:  J Gastroenterol       Date:  2005-03       Impact factor: 7.527

Review 4.  Molecular targeting of glioblastoma: Drug discovery and therapies.

Authors:  Ren-Yuan Bai; Verena Staedtke; Gregory J Riggins
Journal:  Trends Mol Med       Date:  2011-03-14       Impact factor: 11.951

Review 5.  Prostate cancer regulatory networks.

Authors:  Dario C Altieri; Lucia R Languino; Jane B Lian; Janet L Stein; Irwin Leav; Andre J van Wijnen; Zhong Jiang; Gary S Stein
Journal:  J Cell Biochem       Date:  2009-08-01       Impact factor: 4.429

Review 6.  Cancer driver mutations in protein kinase genes.

Authors:  Ali Torkamani; Gennady Verkhivker; Nicholas J Schork
Journal:  Cancer Lett       Date:  2008-12-10       Impact factor: 8.679

7.  Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90.

Authors:  Byoung Heon Kang; Janet Plescia; Ho Young Song; Massimiliano Meli; Giorgio Colombo; Kristin Beebe; Bradley Scroggins; Len Neckers; Dario C Altieri
Journal:  J Clin Invest       Date:  2009-02-23       Impact factor: 14.808

8.  Targeting the human cancer pathway protein interaction network by structural genomics.

Authors:  Yuanpeng Janet Huang; Dehua Hang; Long Jason Lu; Liang Tong; Mark B Gerstein; Gaetano T Montelione
Journal:  Mol Cell Proteomics       Date:  2008-05-18       Impact factor: 5.911

9.  Evolutionary concepts in biobanking - the BC BioLibrary.

Authors:  Peter H Watson; Janet E Wilson-McManus; Rebecca O Barnes; Sara C Giesz; Adrian Png; Richard G Hegele; Jacquelyn N Brinkman; Ian R Mackenzie; David G Huntsman; Anne Junker; Blake Gilks; Erik Skarsgard; Michael Burgess; Samuel Aparicio; Bruce M McManus
Journal:  J Transl Med       Date:  2009-11-12       Impact factor: 5.531

10.  Hierarchical modeling of activation mechanisms in the ABL and EGFR kinase domains: thermodynamic and mechanistic catalysts of kinase activation by cancer mutations.

Authors:  Anshuman Dixit; Gennady M Verkhivker
Journal:  PLoS Comput Biol       Date:  2009-08-28       Impact factor: 4.475

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