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Literature DB >> 15163760

Postattachment events associated with viral entry are necessary for induction of interferon-stimulated genes by human cytomegalovirus.

James R Netterwald¹, Thomas R Jones, William J Britt, Shao-Jun Yang, Ian P McCrone, Hua Zhu.

Abstract

Utilizing a human cytomegalovirus-specific fusion inhibitor and an antiglycoprotein H antibody, we studied the role of virion fusion in interferon-stimulated gene (ISG) induction. Our results indicate that ISG induction does not occur when virion-mediated, post-high-affinity attachment events are inhibited by either reagent. Thus, virion-mediated postattachment events, such as fusion, are required for ISG induction.

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Year: 2004 PMID： 15163760 PMCID： PMC416537 DOI： 10.1128/JVI.78.12.6688-6691.2004

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

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