Literature DB >> 14611860

Thiourea inhibitors of herpes viruses. Part 1: bis-(aryl)thiourea inhibitors of CMV.

Jonathan D Bloom1, Martin J DiGrandi, Russell G Dushin, Kevin J Curran, Adma A Ross, Emily B Norton, Eugene Terefenko, Thomas R Jones, Boris Feld, Stanley A Lang.   

Abstract

Bis-(aryl)thioureas were found to be potent and selective inhibitors of cytomegalovirus (CMV) in cultured HFF cells. Of these, the thiazole analogue 38 was investigated as a potential development candidate.

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Year:  2003        PMID： 14611860     DOI： 10.1016/s0960-894x(03)00586-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Postattachment events associated with viral entry are necessary for induction of interferon-stimulated genes by human cytomegalovirus.

Authors:  James R Netterwald; Thomas R Jones; William J Britt; Shao-Jun Yang; Ian P McCrone; Hua Zhu
Journal:  J Virol       Date:  2004-06       Impact factor: 5.103

Review 2.  Current and potential treatments for ubiquitous but neglected herpesvirus infections.

Authors:  Jonathan E Gable; Timothy M Acker; Charles S Craik
Journal:  Chem Rev       Date:  2014-10-02       Impact factor: 60.622

3.  Discovery of Potent, Orally Bioavailable Inhibitors of Human Cytomegalovirus.

Authors:  Lee Fader; Martine Brault; Jessica Desjardins; Nathalie Dansereau; Louie Lamorte; Sonia Tremblay; François Bilodeau; Josée Bordeleau; Martin Duplessis; Vida Gorys; James Gillard; James L Gleason; Clint James; Marc-André Joly; Cyrille Kuhn; Montse Llinas-Brunet; Laibin Luo; Louis Morency; Sébastien Morin; Mathieu Parisien; Maude Poirier; Carl Thibeault; Thao Trinh; Claudio Sturino; Sanjay Srivastava; Christiane Yoakim; Michael Franti
Journal:  ACS Med Chem Lett       Date:  2016-03-01       Impact factor: 4.345

4.  Specific inhibition of human cytomegalovirus glycoprotein B-mediated fusion by a novel thiourea small molecule.

Authors:  Thomas R Jones; Shi-Wu Lee; Stephen V Johann; Vladimir Razinkov; Robert J Visalli; Boris Feld; Jonathan D Bloom; John O'Connell
Journal:  J Virol       Date:  2004-02       Impact factor: 5.103

5.  Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion.

Authors:  Yuhang Liu; Kyle P Heim; Ye Che; Xiaoyuan Chi; Xiayang Qiu; Seungil Han; Philip R Dormitzer; Xinzhen Yang
Journal:  Sci Adv       Date:  2021-03-05       Impact factor: 14.136

6.  Applications of Cryo-EM in small molecule and biologics drug design.

Authors:  Joshua A Lees; Joao M Dias; Seungil Han
Journal:  Biochem Soc Trans       Date:  2021-12-17       Impact factor: 5.407

7.  Investigation of the reactivity properties of a thiourea derivative with anticancer activity by DFT and MD simulations.

Authors:  Y Sheena Mary; Y Shyma Mary; Anna Bielenica; Stevan Armaković; Sanja J Armaković; Vivek Chandramohan; Manjunath Dammalli
Journal:  J Mol Model       Date:  2021-07-03       Impact factor: 1.810

Review 8.  Mechanochemical synthesis of thioureas, ureas and guanidines.

Authors:  Vjekoslav Štrukil
Journal:  Beilstein J Org Chem       Date:  2017-09-01       Impact factor: 2.883
  8 in total

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