Literature DB >> 15161264

Characterization of the glycosyltransferase activity of desVII: analysis of and implications for the biosynthesis of macrolide antibiotics.

Svetlana A Borisova1, Lishan Zhao, Charles E Melançon III, Chai-Lin Kao, Hung-Wen Liu.   

Abstract

In vitro catalytic activity of DesVII, the glycosyltransferase involved in the biosynthesis of methymycin, neomethymycin, narbomycin, and pikromycin in Streptomyces venezuelae, is described. This is the first report of demonstrated in vitro activity of a glycosyltransferase involved in the biosynthesis of macrolide antibiotics. DesVII is unique among glycosyltransferases in that it requires an additional protein component, DesVIII, as well as basic pH for its full activity.

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Year:  2004        PMID： 15161264     DOI： 10.1021/ja049967j

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  24 in total

1.  Linear aglycones are the substrates for glycosyltransferase DesVII in methymycin biosynthesis: analysis and implications.

Authors:  Chai-Lin Kao; Svetlana A Borisova; Hak Joong Kim; Hung-wen Liu
Journal:  J Am Chem Soc       Date:  2006-05-03       Impact factor: 15.419

2.  Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.

Authors:  Sonia Gullón; Carlos Olano; Mohamed S Abdelfattah; Alfredo F Braña; Jürgen Rohr; Carmen Méndez; José A Salas
Journal:  Appl Environ Microbiol       Date:  2006-06       Impact factor: 4.792

3.  The in vitro characterization of polyene glycosyltransferases AmphDI and NysDI.

Authors:  Changsheng Zhang; Rocco Moretti; Jiqing Jiang; Jon S Thorson
Journal:  Chembiochem       Date:  2008-10-13       Impact factor: 3.164

4.  Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes.

Authors:  Leandro M Garrido; Felipe Lombó; Irfan Baig; Mohammad Nur-E-Alam; Renata L A Furlan; Charlotte C Borda; Alfredo Braña; Carmen Méndez; José A Salas; Jürgen Rohr; Gabriel Padilla
Journal:  Appl Microbiol Biotechnol       Date:  2006-06-30       Impact factor: 4.813

5.  Role of PelF in pel polysaccharide biosynthesis in Pseudomonas aeruginosa.

Authors:  Aamir Ghafoor; Zoe Jordens; Bernd H A Rehm
Journal:  Appl Environ Microbiol       Date:  2013-02-22       Impact factor: 4.792

6.  Glycosylation steps during spiramycin biosynthesis in Streptomyces ambofaciens: involvement of three glycosyltransferases and their interplay with two auxiliary proteins.

Authors:  Hoang Chuong Nguyen; Fatma Karray; Sylvie Lautru; Josette Gagnat; Ahmed Lebrihi; Thuy Duong Ho Huynh; Jean-Luc Pernodet
Journal:  Antimicrob Agents Chemother       Date:  2010-05-03       Impact factor: 5.191

Review 7.  Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function.

Authors:  Jeffrey D Rudolf; Chin-Yuan Chang; Ming Ma; Ben Shen
Journal:  Nat Prod Rep       Date:  2017-08-30       Impact factor: 13.423

8.  In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides.

Authors:  Yanqiu Yuan; Hak Suk Chung; Catherine Leimkuhler; Christopher T Walsh; Daniel Kahne; Suzanne Walker
Journal:  J Am Chem Soc       Date:  2005-10-19       Impact factor: 15.419

Review 9.  Natural-product sugar biosynthesis and enzymatic glycodiversification.

Authors:  Christopher J Thibodeaux; Charles E Melançon; Hung-wen Liu
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

Review 10.  Increasing carbohydrate diversity via amine oxidation: aminosugar, hydroxyaminosugar, nitrososugar, and nitrosugar biosynthesis in bacteria.

Authors:  Shannon C Timmons; Jon S Thorson
Journal:  Curr Opin Chem Biol       Date:  2008-04-18       Impact factor: 8.822
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