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Literature DB >> 15159496

Interaction of medial temporal lobe atrophy and white matter hyperintensities in AD.

W M van der Flier¹, H A M Middelkoop, A W E Weverling-Rijnsburger, F Admiraal-Behloul, A Spilt, E L E M Bollen, R G J Westendorp, M A van Buchem.

Abstract

The authors investigated the interaction between medial temporal lobe (MTL) atrophy and white matter hyperintensities (WMH) in Alzheimer disease (AD). They measured the MTL and WMH on MRI in 58 AD patients and 28 controls. MTL atrophy was associated with an increased risk of AD (OR = 6.2), but there was no significant association between WMH and AD. Moreover, there was an interaction between MTL and WMH (p = 0.045). These results suggest that vascular and Alzheimer-type pathology act in synergy in the clinical syndrome of AD.

Entities: Chemical Disease Species

Mesh：

Year: 2004 PMID： 15159496 DOI： 10.1212/01.wnl.0000125337.65553.8a

Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910

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Cited

16 in total

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2. Measuring longitudinal white matter changes: comparison of a visual rating scale with a volumetric measurement.

Authors: D M J van den Heuvel; V H ten Dam; A J M de Craen; F Admiraal-Behloul; A C G M van Es; W M Palm; A Spilt; E L E M Bollen; G J Blauw; L Launer; R G J Westendorp; M A van Buchem
Journal: AJNR Am J Neuroradiol Date: 2006-04 Impact factor: 3.825

3. Increase in periventricular white matter hyperintensities parallels decline in mental processing speed in a non-demented elderly population.

Authors: D M J van den Heuvel; V H ten Dam; A J M de Craen; F Admiraal-Behloul; H Olofsen; E L E M Bollen; J Jolles; H M Murray; G J Blauw; R G J Westendorp; M A van Buchem
Journal: J Neurol Neurosurg Psychiatry Date: 2006-02 Impact factor: 10.154

4. Post-acquisition processing confounds in brain volumetric quantification of white matter hyperintensities.

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5. Distinctive RNA expression profiles in blood associated with white matter hyperintensities in brain.

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6. Periventricular white matter hyperintensities increase the likelihood of progression from amnestic mild cognitive impairment to dementia.

Authors: Elisabeth C W van Straaten; Danielle Harvey; Philip Scheltens; Frederik Barkhof; Ronald C Petersen; Leon J Thal; Clifford R Jack; Charles DeCarli
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Interaction of medial temporal lobe atrophy and white matter hyperintensities in AD.

Review 1. Patterns of compensation and vulnerability in normal subjects at risk of Alzheimer's disease.

2. Measuring longitudinal white matter changes: comparison of a visual rating scale with a volumetric measurement.

3. Increase in periventricular white matter hyperintensities parallels decline in mental processing speed in a non-demented elderly population.

4. Post-acquisition processing confounds in brain volumetric quantification of white matter hyperintensities.

5. Distinctive RNA expression profiles in blood associated with white matter hyperintensities in brain.

6. Periventricular white matter hyperintensities increase the likelihood of progression from amnestic mild cognitive impairment to dementia.

7. Structural neuroimaging in Altheimer's disease: do white matter hyperintensities matter?

8. Associations between total cerebral blood flow and age related changes of the brain.

9. MRI Markers Predict Cognitive Decline Assessed by Telephone Interview: The Northern Manhattan Study.

Review 10. Cerebral white matter hyperintensities in the prediction of cognitive decline and incident dementia.