Literature DB >> 15157733

Structure and function of poly(A) binding proteins.

Uwe Kühn1, Elmar Wahle.   

Abstract

Poly (A) tails are found at the 3' ends of almost all eukaryotic mRNAs. They are bound by two different poly (A) binding proteins, PABPC in the cytoplasm and PABPN1 in the nucleus. PABPC functions in the initiation of translation and in the regulation of mRNA decay. In both functions, an interaction with the m7G cap at the 5' end of the message plays an important role. PABPN1 is involved in the synthesis of poly (A) tails, increasing the processivity of poly (A) polymerase and contributing to defining the length of a newly synthesized poly (A) tail.

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Year:  2004        PMID： 15157733     DOI： 10.1016/j.bbaexp.2004.03.008

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  138 in total

1.  Dynamical insight into Caenorhabditis elegans eIF4E recognition specificity for mono-and trimethylated structures of mRNA 5' cap.

Authors:  Katarzyna Ruszczyńska-Bartnik; Maciej Maciejczyk; Ryszard Stolarski
Journal:  J Mol Model       Date:  2010-06-10       Impact factor: 1.810

2.  Nuclear import of cytoplasmic poly(A) binding protein restricts gene expression via hyperadenylation and nuclear retention of mRNA.

Authors:  G Renuka Kumar; Britt A Glaunsinger
Journal:  Mol Cell Biol       Date:  2010-09-07       Impact factor: 4.272

Review 3.  Pre-mRNA 3'-end processing complex assembly and function.

Authors:  Serena Chan; Eun-A Choi; Yongsheng Shi
Journal:  Wiley Interdiscip Rev RNA       Date:  2010-10-18       Impact factor: 9.957

Review 4.  The multitasking polyA tail: nuclear RNA maturation, degradation and export.

Authors:  Agnieszka Tudek; Marta Lloret-Llinares; Torben Heick Jensen
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2018-11-05       Impact factor: 6.237

5.  Caenorhabditis elegans decapping proteins: localization and functional analysis of Dcp1, Dcp2, and DcpS during embryogenesis.

Authors:  Sabbi Lall; Fabio Piano; Richard E Davis
Journal:  Mol Biol Cell       Date:  2005-10-05       Impact factor: 4.138

6.  Analysis of a noncanonical poly(A) site reveals a tripartite mechanism for vertebrate poly(A) site recognition.

Authors:  Krishnan Venkataraman; Kirk M Brown; Gregory M Gilmartin
Journal:  Genes Dev       Date:  2005-06-01       Impact factor: 11.361

Review 7.  A systematic analysis of disease-associated variants in the 3' regulatory regions of human protein-coding genes I: general principles and overview.

Authors:  Jian-Min Chen; Claude Férec; David N Cooper
Journal:  Hum Genet       Date:  2006-04-28       Impact factor: 4.132

8.  Evidence that poly(A) binding protein C1 binds nuclear pre-mRNA poly(A) tails.

Authors:  Nao Hosoda; Fabrice Lejeune; Lynne E Maquat
Journal:  Mol Cell Biol       Date:  2006-04       Impact factor: 4.272

Review 9.  Poly(A) binding proteins: are they all created equal?

Authors:  Dixie J Goss; Frida Esther Kleiman
Journal:  Wiley Interdiscip Rev RNA       Date:  2012-12-13       Impact factor: 9.957

10.  Bortezomib induces the formation of nuclear poly(A) RNA granules enriched in Sam68 and PABPN1 in sensory ganglia neurons.

Authors:  Iñigo Casafont; Maria T Berciano; Miguel Lafarga
Journal:  Neurotox Res       Date:  2009-07-16       Impact factor: 3.911
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