BACKGROUND: Social inequalities with regard to hypopharyngeal and laryngeal cancers are observed in many countries. Differences in alcohol and tobacco consumption are often proposed as an explanation for this finding. The aim of this work was to determine the extent to which alcohol and tobacco consumption, and occupational exposure, explain these inequalities. METHODS: A hospital-based case-control study included 504 male cases (105 with glottic, 80 with supraglottic, 97 with epilaryngeal, and 201 with hypopharyngeal cancers) and 242 male controls with non-respiratory cancers. Information about sociodemographic characteristics, detailed alcohol and tobacco consumption, educational level, and occupational history were collected. Odds ratios (OR) and their 95% CI were computed using logistic regressions. RESULTS: When controlling for age only, laryngeal and hypopharyngeal cancers were strongly associated with educational level (OR for low versus high level = 3.22, 95% CI: 2.01, 5.18) and with all indicators based on occupation (OR for ever versus never manual worker = 2.54, 95% CI: 1.78, 3.62). When adjusted for alcohol and tobacco consumption, the OR decreased, but remained significant for occupation (OR for ever manual worker = 1.91, 95% CI: 1.23, 2.95). After further adjustment for occupational exposures, significant associations were no longer observed. Associations differed between subsites. CONCLUSIONS: Social inequalities observed for these cancers are not totally explained by alcohol and tobacco consumption; a substantial proportion could be attributable to occupational exposures.
BACKGROUND: Social inequalities with regard to hypopharyngeal and laryngeal cancers are observed in many countries. Differences in alcohol and tobacco consumption are often proposed as an explanation for this finding. The aim of this work was to determine the extent to which alcohol and tobacco consumption, and occupational exposure, explain these inequalities. METHODS: A hospital-based case-control study included 504 male cases (105 with glottic, 80 with supraglottic, 97 with epilaryngeal, and 201 with hypopharyngeal cancers) and 242 male controls with non-respiratory cancers. Information about sociodemographic characteristics, detailed alcohol and tobacco consumption, educational level, and occupational history were collected. Odds ratios (OR) and their 95% CI were computed using logistic regressions. RESULTS: When controlling for age only, laryngeal and hypopharyngeal cancers were strongly associated with educational level (OR for low versus high level = 3.22, 95% CI: 2.01, 5.18) and with all indicators based on occupation (OR for ever versus never manual worker = 2.54, 95% CI: 1.78, 3.62). When adjusted for alcohol and tobacco consumption, the OR decreased, but remained significant for occupation (OR for ever manual worker = 1.91, 95% CI: 1.23, 2.95). After further adjustment for occupational exposures, significant associations were no longer observed. Associations differed between subsites. CONCLUSIONS: Social inequalities observed for these cancers are not totally explained by alcohol and tobacco consumption; a substantial proportion could be attributable to occupational exposures.
Authors: Rim Khlifi; Pablo Olmedo; Fernando Gil; Feki-Tounsi Molka; Bouthaina Hammami; Rebai Ahmed; Hamza-Chaffai Amel Journal: Environ Sci Pollut Res Int Date: 2014-02 Impact factor: 4.223
Authors: Gioia Di Credico; Valeria Edefonti; Jerry Polesel; Francesco Pauli; Nicola Torelli; Diego Serraino; Eva Negri; Daniele Luce; Isabelle Stucker; Keitaro Matsuo; Paul Brennan; Marta Vilensky; Leticia Fernandez; Maria Paula Curado; Ana Menezes; Alexander W Daudt; Rosalina Koifman; Victor Wunsch-Filho; Ivana Holcatova; Wolfgang Ahrens; Pagona Lagiou; Lorenzo Simonato; Lorenzo Richiardi; Claire Healy; Kristina Kjaerheim; David I Conway; Tatiana V Macfarlane; Peter Thomson; Antonio Agudo; Ariana Znaor; Leonardo F Boaventura Rios; Tatiana N Toporcov; Silvia Franceschi; Rolando Herrero; Joshua Muscat; Andrew F Olshan; Jose P Zevallos; Carlo La Vecchia; Deborah M Winn; Erich M Sturgis; Guojun Li; Eleonora Fabianova; Jolanda Lissowska; Dana Mates; Peter Rudnai; Oxana Shangina; Beata Swiatkowska; Kirsten Moysich; Zuo-Feng Zhang; Hal Morgenstern; Fabio Levi; Elaine Smith; Philip Lazarus; Cristina Bosetti; Werner Garavello; Karl Kelsey; Michael McClean; Heribert Ramroth; Chu Chen; Stephen M Schwartz; Thomas L Vaughan; Tongzhang Zheng; Gwenn Menvielle; Stefania Boccia; Gabriella Cadoni; Richard B Hayes; Mark Purdue; Maura Gillison; Stimson Schantz; Guo-Pei Yu; Hermann Brenner; Gypsyamber D'Souza; Neil D Gross; Shu-Chun Chuang; Paolo Boffetta; Mia Hashibe; Yuan-Chin Amy Lee; Luigino Dal Maso Journal: Oral Oncol Date: 2019-05-17 Impact factor: 5.337
Authors: O Bayer; R Cámara; S R Zeissig; M Ressing; A Dietz; L D Locati; H Ramroth; S Singer Journal: Eur Arch Otorhinolaryngol Date: 2014-10-14 Impact factor: 2.503
Authors: Joshua E Muscat; Hsiao-Pin Liu; Craig Livelsberger; John P Richie; Steven D Stellman Journal: Cancer Causes Control Date: 2012-02-25 Impact factor: 2.506
Authors: N Schmeisser; D I Conway; P A McKinney; A D McMahon; H Pohlabeln; M Marron; S Benhamou; C Bouchardy; G J Macfarlane; T V Macfarlane; P Lagiou; A Lagiou; V Bencko; I Holcátová; F Merletti; L Richiardi; K Kjaerheim; A Agudo; R Talamini; J Polesel; C Canova; L Simonato; R Lowry; A Znaor; C Healy; B E McCarten; M Hashibe; P Brennan; W Ahrens Journal: Eur J Epidemiol Date: 2010-02-09 Impact factor: 8.082
Authors: Rim Khlifi; Pablo Olmedo; Fernando Gil; Molka Feki-Tounsi; Amine Chakroun; Ahmed Rebai; Amel Hamza-Chaffai Journal: Environ Sci Pollut Res Int Date: 2013-04-28 Impact factor: 4.223
Authors: David I Conway; Darren R Brenner; Alex D McMahon; Lorna M D Macpherson; Antonio Agudo; Wolfgang Ahrens; Cristina Bosetti; Hermann Brenner; Xavier Castellsague; Chu Chen; Maria Paula Curado; Otávio A Curioni; Luigino Dal Maso; Alexander W Daudt; José F de Gois Filho; Gypsyamber D'Souza; Valeria Edefonti; Eleonora Fabianova; Leticia Fernandez; Silvia Franceschi; Maura Gillison; Richard B Hayes; Claire M Healy; Rolando Herrero; Ivana Holcatova; Vijayvel Jayaprakash; Karl Kelsey; Kristina Kjaerheim; Sergio Koifman; Carlo La Vecchia; Pagona Lagiou; Philip Lazarus; Fabio Levi; Jolanta Lissowska; Daniele Luce; Tatiana V Macfarlane; Dana Mates; Elena Matos; Michael McClean; Ana M Menezes; Gwenn Menvielle; Franco Merletti; Hal Morgenstern; Kirsten Moysich; Heiko Müller; Joshua Muscat; Andrew F Olshan; Mark P Purdue; Heribert Ramroth; Lorenzo Richiardi; Peter Rudnai; Stimson Schantz; Stephen M Schwartz; Oxana Shangina; Lorenzo Simonato; Elaine Smith; Isabelle Stucker; Erich M Sturgis; Neonila Szeszenia-Dabrowska; Renato Talamini; Peter Thomson; Thomas L Vaughan; Qingyi Wei; Deborah M Winn; Victor Wunsch-Filho; Guo-Pei Yu; Zuo-Feng Zhang; Tongzhang Zheng; Ariana Znaor; Paolo Boffetta; Shu-Chun Chuang; Marianoosh Ghodrat; Yuan-Chin Amy Lee; Mia Hashibe; Paul Brennan Journal: Int J Cancer Date: 2014-08-23 Impact factor: 7.396
Authors: K Markou; A Christoforidou; I Karasmanis; G Tsiropoulos; S Triaridis; I Constantinidis; V Vital; A Nikolaou Journal: Hippokratia Date: 2013-10 Impact factor: 0.471