Literature DB >> 15155673

Contribution of gelatinase, serine protease, and fsr to the pathogenesis of Enterococcus faecalis endophthalmitis.

Michael Engelbert1, Eleftherios Mylonakis, Frederick M Ausubel, Stephen B Calderwood, Michael S Gilmore.   

Abstract

Gelatinase and serine protease were found to contribute in concert to pathogenesis in a rabbit model of endophthalmitis. However, a mutant defective in the fsr regulator was observed to be more attenuated than a mutant rendered defective in the expression of gelatinase and serine protease as the result of a polar transposon insertion into the former. This increased attenuation suggests that there are possible additional pleiotropic effects of the defect in fsr on expression of traits contributing to the pathogenesis of enterococcal infection.

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Year:  2004        PMID： 15155673      PMCID： PMC415677          DOI： 10.1128/IAI.72.6.3628-3633.2004

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  19 in total

Review 1.  Infective endocarditis in adults.

Authors:  E Mylonakis; S B Calderwood
Journal:  N Engl J Med       Date:  2001-11-01       Impact factor: 91.245

Review 2.  Relationships between enterococcal virulence and antimicrobial resistance.

Authors:  L M Mundy; D F Sahm; M Gilmore
Journal:  Clin Microbiol Rev       Date:  2000-10       Impact factor: 26.132

3.  A hemolysin-encoding plasmid contributes to bacterial virulence in experimental Enterococcus faecalis endophthalmitis.

Authors:  S X Stevens; H G Jensen; B D Jett; M S Gilmore
Journal:  Invest Ophthalmol Vis Sci       Date:  1992-04       Impact factor: 4.799

4.  Two-component regulator of Enterococcus faecalis cytolysin responds to quorum-sensing autoinduction.

Authors:  Wolfgang Haas; Brett D Shepard; Michael S Gilmore
Journal:  Nature       Date:  2002-01-03       Impact factor: 49.962

5.  A simple model host for identifying Gram-positive virulence factors.

Authors:  D A Garsin; C D Sifri; E Mylonakis; X Qin; K V Singh; B E Murray; S B Calderwood; F M Ausubel
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-04       Impact factor: 11.205

6.  Effects of Enterococcus faecalis fsr genes on production of gelatinase and a serine protease and virulence.

Authors:  X Qin; K V Singh; G M Weinstock; B E Murray
Journal:  Infect Immun       Date:  2000-05       Impact factor: 3.441

7.  The capsular polysaccharide of Enterococcus faecalis and its relationship to other polysaccharides in the cell wall.

Authors:  Lynn E Hancock; Michael S Gilmore
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-05       Impact factor: 11.205

8.  Virulence effect of Enterococcus faecalis protease genes and the quorum-sensing locus fsr in Caenorhabditis elegans and mice.

Authors:  Costi D Sifri; Eleftherios Mylonakis; Kavindra V Singh; Xiang Qin; Danielle A Garsin; Barbara E Murray; Frederick M Ausubel; Stephen B Calderwood
Journal:  Infect Immun       Date:  2002-10       Impact factor: 3.441

9.  Hemolysin of Streptococcus faecalis subspecies zymogenes contributes to virulence in mice.

Authors:  Y Ike; H Hashimoto; D B Clewell
Journal:  Infect Immun       Date:  1984-08       Impact factor: 3.441

10.  The Enterococcus faecalis fsrB gene, a key component of the fsr quorum-sensing system, is associated with virulence in the rabbit endophthalmitis model.

Authors:  Eleftherios Mylonakis; Michael Engelbert; Xiang Qin; Costi D Sifri; Barbara E Murray; Frederick M Ausubel; Michael S Gilmore; Stephen B Calderwood
Journal:  Infect Immun       Date:  2002-08       Impact factor: 3.441
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  44 in total

Review 1.  Signal transduction, quorum-sensing, and extracellular protease activity in Enterococcus faecalis biofilm formation.

Authors:  Karen Carniol; Michael S Gilmore
Journal:  J Bacteriol       Date:  2004-12       Impact factor: 3.490

2.  Diversity of the fsr-gelE region of the Enterococcus faecalis genome but conservation in strains with partial deletions of the fsr operon.

Authors:  Jessica R Galloway-Peña; Agathe Bourgogne; Xiang Qin; Barbara E Murray
Journal:  Appl Environ Microbiol       Date:  2010-11-19       Impact factor: 4.792

3.  Postoperative Enterococcus faecalis endophthalmitis: virulence factors leading to poor visual outcome.

Authors:  Daisuke Todokoro; Takashi Suzuki; Shinichiro Kobayakawa; Haruyoshi Tomita; Yuichi Ohashi; Hideo Akiyama
Journal:  Jpn J Ophthalmol       Date:  2017-07-13       Impact factor: 2.447

Review 4.  The rise of the Enterococcus: beyond vancomycin resistance.

Authors:  Cesar A Arias; Barbara E Murray
Journal:  Nat Rev Microbiol       Date:  2012-03-16       Impact factor: 60.633

5.  TLR4 contributes to the host response to Klebsiella intraocular infection.

Authors:  Jonathan J Hunt; Roger Astley; Nanette Wheatley; Jin-Town Wang; Michelle C Callegan
Journal:  Curr Eye Res       Date:  2014-03-03       Impact factor: 2.424

6.  Culture-Proven Endophthalmitis After Intravitreal Injection: A 10-Year Analysis.

Authors:  Joseph M Simonett; Austin Igelman; Stanford C Taylor; J Peter Campbell; Thomas S Hwang; Phoebe Lin; Andreas K Lauer; Christina J Flaxel
Journal:  Ophthalmic Surg Lasers Imaging Retina       Date:  2019-01-01       Impact factor: 1.300

7.  Comparison of OG1RF and an isogenic fsrB deletion mutant by transcriptional analysis: the Fsr system of Enterococcus faecalis is more than the activator of gelatinase and serine protease.

Authors:  Agathe Bourgogne; Susan G Hilsenbeck; Gary M Dunny; Barbara E Murray
Journal:  J Bacteriol       Date:  2006-04       Impact factor: 3.490

8.  Multiple roles for Enterococcus faecalis glycosyltransferases in biofilm-associated antibiotic resistance, cell envelope integrity, and conjugative transfer.

Authors:  Jennifer L Dale; Julian Cagnazzo; Chi Q Phan; Aaron M T Barnes; Gary M Dunny
Journal:  Antimicrob Agents Chemother       Date:  2015-04-27       Impact factor: 5.191

9.  Siamycin attenuates fsr quorum sensing mediated by a gelatinase biosynthesis-activating pheromone in Enterococcus faecalis.

Authors:  Jiro Nakayama; Emi Tanaka; Reiko Kariyama; Koji Nagata; Kenzo Nishiguchi; Ritsuko Mitsuhata; Yumi Uemura; Masaru Tanokura; Hiromi Kumon; Kenji Sonomoto
Journal:  J Bacteriol       Date:  2006-10-27       Impact factor: 3.490

10.  An AraC-type transcriptional regulator encoded on the Enterococcus faecalis pathogenicity island contributes to pathogenesis and intracellular macrophage survival.

Authors:  Phillip S Coburn; Arto S Baghdayan; G T Dolan; Nathan Shankar
Journal:  Infect Immun       Date:  2008-09-29       Impact factor: 3.441
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