Literature DB >> 12117982

The Enterococcus faecalis fsrB gene, a key component of the fsr quorum-sensing system, is associated with virulence in the rabbit endophthalmitis model.

Eleftherios Mylonakis1, Michael Engelbert, Xiang Qin, Costi D Sifri, Barbara E Murray, Frederick M Ausubel, Michael S Gilmore, Stephen B Calderwood.   

Abstract

We used a rabbit endophthalmitis model to explore the role of fsrB, a gene required for the function of the fsr quorum-sensing system of Enterococcus faecalis, in pathogenicity. A nonpolar deletion mutant of fsrB had significantly reduced virulence compared to wild type. Complementation of mutation restored virulence. These data corroborate the role of fsrB in E. faecalis pathogenesis and suggest that the rabbit endophthalmitis model can be used to study the in vivo role of quorum sensing.

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Year:  2002        PMID： 12117982      PMCID： PMC128160          DOI： 10.1128/IAI.70.8.4678-4681.2002

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  20 in total

Review 1.  Vancomycin-resistant enterococcal infections.

Authors:  B E Murray
Journal:  N Engl J Med       Date:  2000-03-09       Impact factor: 91.245

Review 2.  Infective endocarditis in adults.

Authors:  E Mylonakis; S B Calderwood
Journal:  N Engl J Med       Date:  2001-11-01       Impact factor: 91.245

Review 3.  Staphylococcus aureus and Staphylococcus epidermidis peptide pheromones produced by the accessory gene regulator agr system.

Authors:  M Otto
Journal:  Peptides       Date:  2001-10       Impact factor: 3.750

4.  Characterization of fsr, a regulator controlling expression of gelatinase and serine protease in Enterococcus faecalis OG1RF.

Authors:  X Qin; K V Singh; G M Weinstock; B E Murray
Journal:  J Bacteriol       Date:  2001-06       Impact factor: 3.490

5.  Relationships between Staphylococcus aureus genetic background, virulence factors, agr groups (alleles), and human disease.

Authors:  Sophie Jarraud; Christophe Mougel; Jean Thioulouse; Gerard Lina; Hélène Meugnier; Françoise Forey; Xavier Nesme; Jerome Etienne; François Vandenesch
Journal:  Infect Immun       Date:  2002-02       Impact factor: 3.441

Review 6.  Bacterial endophthalmitis: epidemiology, therapeutics, and bacterium-host interactions.

Authors:  Michelle C Callegan; Michael Engelbert; David W Parke; Bradley D Jett; Michael S Gilmore
Journal:  Clin Microbiol Rev       Date:  2002-01       Impact factor: 26.132

7.  Two-component regulator of Enterococcus faecalis cytolysin responds to quorum-sensing autoinduction.

Authors:  Wolfgang Haas; Brett D Shepard; Michael S Gilmore
Journal:  Nature       Date:  2002-01-03       Impact factor: 49.962

8.  Gelatinase biosynthesis-activating pheromone: a peptide lactone that mediates a quorum sensing in Enterococcus faecalis.

Authors:  J Nakayama; Y Cao; T Horii; S Sakuda; A D Akkermans; W M de Vos; H Nagasawa
Journal:  Mol Microbiol       Date:  2001-07       Impact factor: 3.501

9.  A simple model host for identifying Gram-positive virulence factors.

Authors:  D A Garsin; C D Sifri; E Mylonakis; X Qin; K V Singh; B E Murray; S B Calderwood; F M Ausubel
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-04       Impact factor: 11.205

10.  Pathogenesis of gram-positive bacterial endophthalmitis.

Authors:  M C Callegan; M C Booth; B D Jett; M S Gilmore
Journal:  Infect Immun       Date:  1999-07       Impact factor: 3.441
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  41 in total

1.  Enterococcus faecalis mutations affecting virulence in the Caenorhabditis elegans model host.

Authors:  Arash Maadani; Kristina A Fox; Elftherios Mylonakis; Danielle A Garsin
Journal:  Infect Immun       Date:  2007-02-16       Impact factor: 3.441

2.  Enterococcus faecalis mammalian virulence-related factors exhibit potent pathogenicity in the Arabidopsis thaliana plant model.

Authors:  Ajay K Jha; Harsh P Bais; Jorge M Vivanco
Journal:  Infect Immun       Date:  2005-01       Impact factor: 3.441

3.  Diversity of the fsr-gelE region of the Enterococcus faecalis genome but conservation in strains with partial deletions of the fsr operon.

Authors:  Jessica R Galloway-Peña; Agathe Bourgogne; Xiang Qin; Barbara E Murray
Journal:  Appl Environ Microbiol       Date:  2010-11-19       Impact factor: 4.792

4.  Postoperative Enterococcus faecalis endophthalmitis: virulence factors leading to poor visual outcome.

Authors:  Daisuke Todokoro; Takashi Suzuki; Shinichiro Kobayakawa; Haruyoshi Tomita; Yuichi Ohashi; Hideo Akiyama
Journal:  Jpn J Ophthalmol       Date:  2017-07-13       Impact factor: 2.447

5.  Enterococcus faecalis virulence regulator FsrA binding to target promoters.

Authors:  María Florencia Del Papa; Marta Perego
Journal:  J Bacteriol       Date:  2011-01-21       Impact factor: 3.490

Review 6.  The rise of the Enterococcus: beyond vancomycin resistance.

Authors:  Cesar A Arias; Barbara E Murray
Journal:  Nat Rev Microbiol       Date:  2012-03-16       Impact factor: 60.633

7.  Comparison of OG1RF and an isogenic fsrB deletion mutant by transcriptional analysis: the Fsr system of Enterococcus faecalis is more than the activator of gelatinase and serine protease.

Authors:  Agathe Bourgogne; Susan G Hilsenbeck; Gary M Dunny; Barbara E Murray
Journal:  J Bacteriol       Date:  2006-04       Impact factor: 3.490

8.  Multiple roles for Enterococcus faecalis glycosyltransferases in biofilm-associated antibiotic resistance, cell envelope integrity, and conjugative transfer.

Authors:  Jennifer L Dale; Julian Cagnazzo; Chi Q Phan; Aaron M T Barnes; Gary M Dunny
Journal:  Antimicrob Agents Chemother       Date:  2015-04-27       Impact factor: 5.191

9.  Siamycin attenuates fsr quorum sensing mediated by a gelatinase biosynthesis-activating pheromone in Enterococcus faecalis.

Authors:  Jiro Nakayama; Emi Tanaka; Reiko Kariyama; Koji Nagata; Kenzo Nishiguchi; Ritsuko Mitsuhata; Yumi Uemura; Masaru Tanokura; Hiromi Kumon; Kenji Sonomoto
Journal:  J Bacteriol       Date:  2006-10-27       Impact factor: 3.490

10.  Importance of the ebp (endocarditis- and biofilm-associated pilus) locus in the pathogenesis of Enterococcus faecalis ascending urinary tract infection.

Authors:  Kavindra V Singh; Sreedhar R Nallapareddy; Barbara E Murray
Journal:  J Infect Dis       Date:  2007-04-26       Impact factor: 5.226
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