Literature DB >> 15155243

Immunopharmacology of CpG oligodeoxynucleotides and ribavirin.

Jörg Vollmer1, Robert Rankin, Hanna Hartmann, Marion Jurk, Ulrike Samulowitz, Tanja Wader, Andrea Janosch, Christian Schetter, Arthur M Krieg.   

Abstract

To investigate their potential mechanisms of action, the nucleoside analogue ribavirin and a TLR9 agonist were compared. The CpG oligodeoxynucleotides (ODN) demonstrated strong TLR9-related Th1-type effects, and ribavirin appeared only to mediate signaling in TLR-transfected cells. CpG ODN represent a promising new type of therapeutic drug for hepatitis C or other infectious diseases.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15155243      PMCID： PMC415599          DOI： 10.1128/AAC.48.6.2314-2317.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

Review 1.  Mechanism of action of ribavirin in the combination treatment of chronic HCV infection.

Authors:  Johnson Y N Lau; Robert C Tam; T Jake Liang; Zhi Hong
Journal:  Hepatology       Date:  2002-05       Impact factor: 17.425

2.  Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848.

Authors:  Marion Jurk; Florian Heil; Jörg Vollmer; Christian Schetter; Arthur M Krieg; Hermann Wagner; Grayson Lipford; Stefan Bauer
Journal:  Nat Immunol       Date:  2002-06       Impact factor: 25.606

Review 3.  Antiviral drugs in the immunocompetent host: part I. Treatment of hepatitis, cytomegalovirus, and herpes infections.

Authors:  Richard Colgan; Robert Michocki; Lisa Greisman; Tracy A Wolff Moore
Journal:  Am Fam Physician       Date:  2003-02-15       Impact factor: 3.292

Review 4.  Toll-like receptors as potential therapeutic targets for multiple diseases.

Authors:  Claudia Zuany-Amorim; John Hastewell; Christoph Walker
Journal:  Nat Rev Drug Discov       Date:  2002-10       Impact factor: 84.694

5.  Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition.

Authors:  S Bauer; C J Kirschning; H Häcker; V Redecke; S Hausmann; S Akira; H Wagner; G B Lipford
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-24       Impact factor: 11.205

Review 6.  Recent advances in the development of immunostimulatory oligonucleotides.

Authors:  Eugen Uhlmann; Joerg Vollmer
Journal:  Curr Opin Drug Discov Devel       Date:  2003-03

7.  Crystal structure of Tritrichomonas foetus inosine monophosphate dehydrogenase in complex with the inhibitor ribavirin monophosphate reveals a catalysis-dependent ion-binding site.

Authors:  Glen L Prosise; Jim Zhen Wu; Hartmut Luecke
Journal:  J Biol Chem       Date:  2002-09-13       Impact factor: 5.157

Review 8.  The hepatitis C virus persistence: how to evade the immune system?

Authors:  Nicole Pavio; Michael M C Lai
Journal:  J Biosci       Date:  2003-04       Impact factor: 1.826

9.  The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily.

Authors:  Florian Heil; Parviz Ahmad-Nejad; Hiroaki Hemmi; Hubertus Hochrein; Franziska Ampenberger; Tanja Gellert; Harald Dietrich; Grayson Lipford; Kiyoshi Takeda; Shizuo Akira; Hermann Wagner; Stefan Bauer
Journal:  Eur J Immunol       Date:  2003-11       Impact factor: 5.532

10.  Evidence of viral replication in circulating dendritic cells during hepatitis C virus infection.

Authors:  Nadège Goutagny; Ahmed Fatmi; Victor De Ledinghen; François Penin; Patrice Couzigou; Geneviève Inchauspé; Christine Bain
Journal:  J Infect Dis       Date:  2003-05-29       Impact factor: 5.226
View more
  7 in total

1.  Effective posttransplant antitumor immunity is associated with TLR-stimulating nucleic acid-immunoglobulin complexes in humans.

Authors:  Yun Lin; Li Zhang; Ann X Cai; Mark Lee; Wandi Zhang; Donna Neuberg; Christine M Canning; Robert J Soiffer; Edwin P Alyea; Jerome Ritz; Nir Hacohen; Terry K Means; Catherine J Wu
Journal:  J Clin Invest       Date:  2011-03-14       Impact factor: 14.808

2.  Distinct Toll-like receptor expression in monocytes and T cells in chronic HCV infection.

Authors:  Angela Dolganiuc; Catherine Garcia; Karen Kodys; Gyongyi Szabo
Journal:  World J Gastroenterol       Date:  2006-02-28       Impact factor: 5.742

3.  Microbial Translocation and B Cell Dysfunction in Human Immunodeficiency Virus Disease.

Authors:  Wei Jiang
Journal:  Am J Immunol       Date:  2012

4.  Ex vivo host and parasite response to antileishmanial drugs and immunomodulators.

Authors:  Laura Gonzalez-Fajardo; Olga Lucía Fernández; Diane McMahon-Pratt; Nancy Gore Saravia
Journal:  PLoS Negl Trop Dis       Date:  2015-05-29

5.  Differential expression of viral PAMP receptors mRNA in peripheral blood of patients with chronic hepatitis C infection.

Authors:  Rafael Atencia; Francisco J Bustamante; Andrés Valdivieso; Arantza Arrieta; Marta Riñón; Alvaro Prada; Natalia Maruri
Journal:  BMC Infect Dis       Date:  2007-11-19       Impact factor: 3.090

6.  Immunostimulatory effects of three classes of CpG oligodeoxynucleotides on PBMC from HCV chronic carriers.

Authors:  Curtis L Cooper; Navneet K Ahluwalia; Susan M Efler; Jörg Vollmer; Arthur M Krieg; Heather L Davis
Journal:  J Immune Based Ther Vaccines       Date:  2008-06-09

7.  Distinct Toll-like Receptor 3 and 7 Expression in Peripheral Blood Mononuclear Cells From Patients with Chronic Hepatitis C Infection.

Authors:  Mahsa Motavaf; Fatemeh Noorbakhsh; Seyed Moayed Alavian; Zohreh Sharifi
Journal:  Hepat Mon       Date:  2014-04-07       Impact factor: 0.660
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.