Literature DB >> 15155241

Enhanced production of farnesol by Candida albicans treated with four azoles.

Jacob M Hornby1, Kenneth W Nickerson.   

Abstract

The dimorphic fungus Candida albicans excretes farnesol, which is produced enzymatically from the sterol biosynthetic intermediate farnesyl pyrophosphate. Inhibition of C. albicans by four azole antifungals, fluconazole, ketoconazole, miconazole, and clotrimazole, caused elevated farnesol production (10- to 45-fold). Furthermore, farnesol production occurs in both laboratory strains and clinical isolates (J. M. Hornby et al., Appl. Environ. Microbiol. 67:2982-2992, 2001) of C. albicans.

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Year:  2004        PMID： 15155241      PMCID： PMC415631          DOI： 10.1128/AAC.48.6.2305-2307.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  Purification and characterization of an autoregulatory substance capable of regulating the morphological transition in Candida albicans.

Authors:  K B Oh; H Miyazawa; T Naito; H Matsuoka
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-27       Impact factor: 11.205

2.  The trailing end point phenotype in antifungal susceptibility testing is pH dependent.

Authors:  K A Marr; T R Rustad; J H Rex; T C White
Journal:  Antimicrob Agents Chemother       Date:  1999-06       Impact factor: 5.191

3.  Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol.

Authors:  J M Hornby; E C Jensen; A D Lisec; J J Tasto; B Jahnke; R Shoemaker; P Dussault; K W Nickerson
Journal:  Appl Environ Microbiol       Date:  2001-07       Impact factor: 4.792

4.  Effects of azole antifungal drugs on the transition from yeast cells to hyphae in susceptible and resistant isolates of the pathogenic yeast Candida albicans.

Authors:  K C Ha; T C White
Journal:  Antimicrob Agents Chemother       Date:  1999-04       Impact factor: 5.191

5.  The mode of antifungal action of tolnaftate.

Authors:  K J Barrett-Bee; A C Lane; R W Turner
Journal:  J Med Vet Mycol       Date:  1986-04

Review 6.  Discovery, biosynthesis, and mechanism of action of the zaragozic acids: potent inhibitors of squalene synthase.

Authors:  J D Bergstrom; C Dufresne; G F Bills; M Nallin-Omstead; K Byrne
Journal:  Annu Rev Microbiol       Date:  1995       Impact factor: 15.500

Review 7.  Physiological implications of sterol biosynthesis in yeast.

Authors:  L W Parks; W M Casey
Journal:  Annu Rev Microbiol       Date:  1995       Impact factor: 15.500

8.  Farnesol biosynthesis in Candida albicans: cellular response to sterol inhibition by zaragozic acid B.

Authors:  Jacob M Hornby; Bessie W Kebaara; Kenneth W Nickerson
Journal:  Antimicrob Agents Chemother       Date:  2003-07       Impact factor: 5.191

9.  Effects of imidazole- and triazole-derivative antifungal compounds on the growth and morphological development of Candida albicans hyphae.

Authors:  F C Odds; A Cockayne; J Hayward; A B Abbott
Journal:  J Gen Microbiol       Date:  1985-10

10.  Quorum sensing in Candida albicans: probing farnesol's mode of action with 40 natural and synthetic farnesol analogs.

Authors:  Roman Shchepin; Jacob M Hornby; Erin Burger; Timothy Niessen; Patrick Dussault; Kenneth W Nickerson
Journal:  Chem Biol       Date:  2003-08
  10 in total
  38 in total

Review 1.  Talking to themselves: autoregulation and quorum sensing in fungi.

Authors:  Deborah A Hogan
Journal:  Eukaryot Cell       Date:  2006-04

Review 2.  Quorum sensing in dimorphic fungi: farnesol and beyond.

Authors:  Kenneth W Nickerson; Audrey L Atkin; Jacob M Hornby
Journal:  Appl Environ Microbiol       Date:  2006-06       Impact factor: 4.792

Review 3.  Candida and invasive candidiasis: back to basics.

Authors:  C S-Y Lim; R Rosli; H F Seow; P P Chong
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2011-05-05       Impact factor: 3.267

4.  Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum.

Authors:  Daniel D Mosel; Raluca Dumitru; Jacob M Hornby; Audrey L Atkin; Kenneth W Nickerson
Journal:  Appl Environ Microbiol       Date:  2005-08       Impact factor: 4.792

5.  Cell cycle dynamics and quorum sensing in Candida albicans chlamydospores are distinct from budding and hyphal growth.

Authors:  Stephen W Martin; Lois M Douglas; James B Konopka
Journal:  Eukaryot Cell       Date:  2005-07

6.  The in vitro and in vivo efficacy of fluconazole in combination with farnesol against Candida albicans isolates using a murine vulvovaginitis model.

Authors:  Aliz Bozó; Marianna Domán; László Majoros; Gábor Kardos; István Varga; Renátó Kovács
Journal:  J Microbiol       Date:  2016-10-29       Impact factor: 3.422

7.  The effect of cinnamaldehyde on the growth and the morphology of Candida albicans.

Authors:  Yuuki Taguchi; Yayoi Hasumi; Shigeru Abe; Yayoi Nishiyama
Journal:  Med Mol Morphol       Date:  2013-01-17       Impact factor: 2.309

8.  Morphogenesis control in Candida albicans and Candida dubliniensis through signaling molecules produced by planktonic and biofilm cells.

Authors:  Margarida Martins; Mariana Henriques; Joana Azeredo; Sílvia M Rocha; Manuel A Coimbra; Rosário Oliveira
Journal:  Eukaryot Cell       Date:  2007-11-02

9.  Effect of farnesol on a mouse model of systemic candidiasis, determined by use of a DPP3 knockout mutant of Candida albicans.

Authors:  Dhammika H M L P Navarathna; Jacob M Hornby; Navasona Krishnan; Anne Parkhurst; Gerald E Duhamel; Kenneth W Nickerson
Journal:  Infect Immun       Date:  2007-02-05       Impact factor: 3.441

Review 10.  Lipid signaling in pathogenic fungi.

Authors:  Ryan Rhome; Maurizio Del Poeta
Journal:  Annu Rev Microbiol       Date:  2009       Impact factor: 15.500
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