| Literature DB >> 1515247 |
I Moreno1, R Rosell, A Abad, A Barnadas, J Carles, N Ribelles, V Solano, A Font.
Abstract
Antiemetic activity of three protracted regimens for the control of cisplatin-evoked delayed emesis was explored. 63 patients were randomly assigned to receive one of three protracted antiemetic schedules over 4 days. Group C patients received dexamethasone 8 mg twice daily on days 2 and 3, then 4 mg twice daily on days 4 and 5; in group B, alizapride 2.5 mg/kg four times daily on days 2-5 plus dexamethasone as in group C was administered; and in group A, metoclopramide 0.5 mg/kg four times daily on days 2-5 plus dexamethasone was given at the same dose-schedule as in groups C and B. Complete protection from delayed vomiting was achieved in 44% of group C, 30% of B and 70% of group A (P = 0.02). Mild side-effects were noted in all three groups. A higher complete protection for delayed emesis was obtained in metoclopramide-dexamethasone-treated patients. Neither of the regimens used in the protection of delayed emesis controlled late nausea.Entities:
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Year: 1992 PMID： 1515247 DOI： 10.1016/0959-8049(92)90515-4
Source DB: PubMed Journal: Eur J Cancer ISSN： 0959-8049 Impact factor: 9.162