| Literature DB >> 15151939 |
M von Bergwelt-Baildon1, B Maecker, J Schultze, J G Gribben.
Abstract
Despite encouraging scientific and therapeutic advances, chronic lymphocytic leukemia (CLL) principally remains an incurable disease. Allogeneic transplantation represents the only curative approach, but is marked by high mortality. Novel and less toxic treatment modalities are needed. Immunotherapeutic approaches have clearly demonstrated potential effectiveness in CLL and other B-cell malignancies. To successfully direct immunity against CLL, highly immunogenic tumor cells or tumor-antigen-loaded antigen-presenting cells are necessary. The CD40-CD40L interaction has been shown to significantly increase antigen presentation in normal and malignant B-cells. Here we discuss biology and potential therapeutic applications of the CD40-system in CLL.Entities:
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Year: 2004 PMID： 15151939 DOI： 10.1093/annonc/mdh213
Source DB: PubMed Journal: Ann Oncol ISSN： 0923-7534 Impact factor: 32.976