| Literature DB >> 27132279 |
Nathan H Fowler1, Chan Yoon Cheah2, Randy D Gascoyne3, John Gribben4, Sattva S Neelapu5, Paolo Ghia6, Catherine Bollard7, Stephen Ansell8, Michael Curran5, Wyndham H Wilson9, Susan O'Brien10, Cliona Grant11, Richard Little12, Thorsten Zenz13, Loretta J Nastoupil5, Kieron Dunleavy9.
Abstract
The tumor microenvironment is the cellular and molecular environment in which the tumor exists and with which it continuously interacts. In B-cell lymphomas, this microenvironment is intriguing in that it plays critical roles in the regulation of tumor cell survival and proliferation, fostering immune escape as well as the development of treatment resistance. The purpose of this review is to summarize the proceedings of the Second Annual Summit on the Immune Microenvironment in Hematologic Malignancies that took place on September 11-12, 2014 in Dublin, Ireland. We provide a timely overview of the composition and biological relevance of the cellular and molecular microenvironment interface and discuss the role of interactions between the microenvironment and neoplastic cells in a variety of B-cell lymphomas. In addition, we focus on various novel therapeutic strategies that target the tumor microenvironment, including agents that modulate B-cell receptor pathways and immune-checkpoints, chimeric antigen receptor T cells and immunomodulatory agents. Copyright© Ferrata Storti Foundation.Entities:
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Year: 2016 PMID： 27132279 PMCID： PMC5004369 DOI： 10.3324/haematol.2015.139493
Source DB: PubMed Journal: Haematologica ISSN： 0390-6078 Impact factor: 9.941