| Literature DB >> 15151394 |
Ging S Lee1, Jude N Bashara, Ghiwa Sabih, Asmik Oganesyan, Gayane Godjoian, Hieu M Duong, Eric R Marinez, Carlos G Gutiérrez.
Abstract
New adamantane derivatives 1 and 2 that bear functionalized one-carbon extensions at all four bridgehead positions have been prepared. Radical nucleophilic substitution (S(RN)1) reaction of 1,3,5,7-tetrabromoadamantane with cyanide produces 1,3,5,7-tetracyanoadamantane (1), which was reduced with borane reagents to 1,3,5,7-tetrakis(aminomethyl)adamantane (2). Improvements in the preparation of 1,3,5,7-tetrahaloadamantanes (halogen = Br, Cl, I) are also reported. [structure--see text]Entities:
Mesh：
Substances：
Year: 2004 PMID： 15151394 DOI： 10.1021/ol036526g
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005