Literature DB >> 15151138

[The "incorrect" laboratory result. II: Common misinterpretations of laboratory results].

J Thiery1, G M Fiedler.   

Abstract

In the second part of our review the most frequent misinterpretations of laboratory results in the daily clinical practise are discussed. Special attention has been given to frequent misinterpretations in the analysis of electrolytes, enzymes and hormones in plasma/serum (pseudohyperkalemia, macroenzymes, macroprolactinemia). Misinterpretations of the testing of blood gases, serum glucose, lipid concentrations, and calcium are described in greater detail. In addition, potential errors in the urinanalysis and the importance of adequate sampling of blood specimens for coagulation testing are described. The hematological results can be misinterpreted in the presence of EDTA-induced pseudothrombocytenia and of irregular immunoglobulines. Immunological methods themselves can lead to misinterpretations of the laboratory result, e. g. caused by the high dose hook effect and interferences in the presence of rheumatoid factor or HAMA. Finally clinical relevant errors in the therapeutic drug monitoring are discussed which are associated with the limited specificity of the antibodies in the commonly used immunological tests.

Entities:  

Mesh:

Year:  2004        PMID: 15151138     DOI: 10.1007/s00108-004-1150-6

Source DB:  PubMed          Journal:  Internist (Berl)        ISSN: 0020-9554            Impact factor:   0.743


  7 in total

1.  Macroenzymes: too often overlooked.

Authors:  Chiara Briani; Martina Zaninotto; Massimo Forni; Patrizia Burra
Journal:  J Hepatol       Date:  2003-01       Impact factor: 25.083

2.  A rare but important cause for a raised serum creatine kinase concentration: two case reports and a literature review.

Authors:  B Galarraga; D Sinclair; M N Fahie-Wilson; F C McCrae; R G Hull; J M Ledingham
Journal:  Rheumatology (Oxford)       Date:  2003-01       Impact factor: 7.580

3.  Macro creatine kinase type 2: results of a prospective study in hospitalized patients.

Authors:  W Stein; J Bohner; W Renn; R Maulbetsch
Journal:  Clin Chem       Date:  1985-12       Impact factor: 8.327

4.  Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus.

Authors:  David B Sacks; David E Bruns; David E Goldstein; Noel K Maclaren; Jay M McDonald; Marian Parrott
Journal:  Clin Chem       Date:  2002-03       Impact factor: 8.327

5.  Macroprolactinemia: predictability on clinical basis and detection by PEG precipitation with two different immunometric methods.

Authors:  P Amadori; C Dilberis; A Marcolla; M Pinamonti; P Menapace; F Dal Bosco
Journal:  J Endocrinol Invest       Date:  2003-02       Impact factor: 4.256

6.  Pseudohyperkalemia in extreme leukocytosis.

Authors:  G Colussi; D Cipriani
Journal:  Am J Nephrol       Date:  1995       Impact factor: 3.754

7.  Frequent misdiagnosis and mismanagement of hyperprolactinemic patients before the introduction of macroprolactin screening: application of a new strict laboratory definition of macroprolactinemia.

Authors:  Abdulwahab M Suliman; Thomas P Smith; James Gibney; T Joseph McKenna
Journal:  Clin Chem       Date:  2003-09       Impact factor: 8.327

  7 in total
  2 in total

1.  [Pareses, myalgias, and massive CK elevation: a severe neurological disorder?].

Authors:  Johannes Steinfurt; Markus C Müller; Anke Seidel; Richard Salm; Andreas Ochs
Journal:  Med Klin (Munich)       Date:  2010-07-30

2.  [Thrombocytopenia in a patient with coronary artery disease after percutaneous coronary intervention].

Authors:  S M Said; R Prondzinsky
Journal:  Internist (Berl)       Date:  2008-05       Impact factor: 0.743

  2 in total

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