Literature DB >> 15149793

Pressure-inactivated FMDV: a potential vaccine.

Daniella Ishimaru1, Daniel Sá-Carvalho, Jerson L Silva.   

Abstract

Foot-and-mouth disease virus (FMDV) is the causative agent of the foot-and-mouth disease (FMD). Alternative FMD vaccines have been pursued due to important disadvantages of the one currently in use. High hydrostatic pressure (HP) has been observed to inactivate some viruses. Here, we investigated the effects of HP on FMDV O1 Campos-Vallée (CVa) infectivity. A treatment consisting of 2.5 kbar at -15 degrees C and 1M urea, completely abolished FMDV infectivity, maintaining the integrity of its capsid structure. Moreover, its ability to elicit neutralizing antibody production in rabbits was preserved. Taken together, our results suggest that HP could be a safe, simple, cheap and reproducible way for viral vaccine production.

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Year:  2004        PMID： 15149793     DOI： 10.1016/j.vaccine.2003.10.034

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  7 in total

1.  Lack of correlation between virus barosensitivity and the presence of a viral envelope during inactivation of human rotavirus, vesicular stomatitis virus, and avian metapneumovirus by high-pressure processing.

Authors:  Fangfei Lou; Hudaa Neetoo; Junan Li; Haiqiang Chen; Jianrong Li
Journal:  Appl Environ Microbiol       Date:  2011-10-14       Impact factor: 4.792

2.  VP4 protein from human rhinovirus 14 is released by pressure and locked in the capsid by the antiviral compound WIN.

Authors:  Rafael B Gonçalves; Ygara S Mendes; Marcia R Soares; Umesh Katpally; Thomas J Smith; Jerson L Silva; Andréa C Oliveira
Journal:  J Mol Biol       Date:  2006-11-11       Impact factor: 5.469

Review 3.  Biomolecules under Pressure: Phase Diagrams, Volume Changes, and High Pressure Spectroscopic Techniques.

Authors:  László Smeller
Journal:  Int J Mol Sci       Date:  2022-05-20       Impact factor: 6.208

Review 4.  Technical transformation of biodefense vaccines.

Authors:  Shan Lu; Shixia Wang
Journal:  Vaccine       Date:  2009-11-05       Impact factor: 3.641

5.  Inactivation of avian influenza viruses by hydrostatic pressure as a potential vaccine development approach.

Authors:  Shana Priscila Coutinho Barroso; Ana Clara Vicente Dos Santos; Patrícia Souza Dos Santos; José Nelson Dos Santos Silva Couceiro; Davis Fernandes Ferreira; Dirlei Nico; Alexandre Morrot; Jerson Lima Silva; Andrea Cheble de Oliveira
Journal:  Access Microbiol       Date:  2021-04-13

6.  Potency under pressure: the impact of hydrostatic pressure on antigenic properties of influenza virus hemagglutinin.

Authors:  Schafer L Eichelberger; Ishrat Sultana; Jin Gao; Melkamu Getie-Kebtie; Michail Alterman; Maryna C Eichelberger
Journal:  Influenza Other Respir Viruses       Date:  2013-03-17       Impact factor: 4.380

7.  Full inactivation of human influenza virus by high hydrostatic pressure preserves virus structure and membrane fusion while conferring protection to mice against infection.

Authors:  Carlos H Dumard; Shana P C Barroso; Guilherme A P de Oliveira; Carlos A M Carvalho; Andre M O Gomes; José Nelson S S Couceiro; Davis F Ferreira; Dirlei Nico; Andrea C Oliveira; Jerson L Silva; Patrícia S Santos
Journal:  PLoS One       Date:  2013-11-25       Impact factor: 3.240
  7 in total

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