Literature DB >> 15149692

Design and synthesis of dysidiolide analogs from vitamin D3: novel class of Cdc25A inhibitors.

Rumiko Shimazawa1, Toshiyuki Suzuki, Kosuke Dodo, Ryuichi Shirai.   

Abstract

Potent dysidiolide analogs were synthesized by structural hybridization of dysidiolide and vitamin D(3). These analogs exhibited strong inhibitory activity toward dual-specificity phosphatase Cdc25A (IC(50)=0.44-0.89 microM).

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Year:  2004        PMID: 15149692     DOI: 10.1016/j.bmcl.2004.03.100

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

Review 1.  A Comprehensive Overview of the Developments of Cdc25 Phosphatase Inhibitors.

Authors:  Ahmed Bakr Abdelwahab; Eslam Reda El-Sawy; Atef G Hanna; Denyse Bagrel; Gilbert Kirsch
Journal:  Molecules       Date:  2022-04-07       Impact factor: 4.927

2.  LGH00031, a novel ortho-quinonoid inhibitor of cell division cycle 25B, inhibits human cancer cells via ROS generation.

Authors:  Yu-bo Zhou; Xu Feng; Li-na Wang; Jun-qing Du; Yue-yang Zhou; Hai-ping Yu; Yi Zang; Jing-ya Li; Jia Li
Journal:  Acta Pharmacol Sin       Date:  2009-09       Impact factor: 6.150

  2 in total

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