| Literature DB >> 15149682 |
Robert L Dow1, Ernest S Paight, Steven R Schneider, John R Hadcock, Diane M Hargrove, Kelly A Martin, Tristan S Maurer, Nancy A Nardone, David A Tess, Paul DaSilva-Jardine.
Abstract
A series of sulfamide-based analogs related to L-796568 were prepared and evaluated for their biological activity at the human beta(3)-adrenergic receptor (AR). This modification allows for a significant reduction in molecular weight, while maintaining single-digit nanomolar potencies at the beta(3)-AR and high selectivities versus the beta(2)- or beta(3)-AR.Entities:
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Year: 2004 PMID： 15149682 DOI： 10.1016/j.bmcl.2004.03.089
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823