Literature DB >> 15149665

In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase.

Derek B Lowe1, Steven Magnuson, Ning Qi, Ann-Marie Campbell, James Cook, Zhenqiu Hong, Ming Wang, Mareli Rodriguez, Furahi Achebe, Harold Kluender, Wai C Wong, William H Bullock, Arthur I Salhanick, Terri Witman-Jones, Mary E Bowling, Christine Keiper, Kevin B Clairmont.   

Abstract

A series of (5-(2H)-isoxazolonyl) ureas were developed as nanomolar inhibitors of hormone-sensitive lipase, an enzyme of potential importance in the treatment of diabetes.

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Year:  2004        PMID: 15149665     DOI: 10.1016/j.bmcl.2004.04.015

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  13 in total

1.  Human adipose triglyceride lipase (PNPLA2) is not regulated by obesity and exhibits low in vitro triglyceride hydrolase activity.

Authors:  A Mairal; D Langin; P Arner; J Hoffstedt
Journal:  Diabetologia       Date:  2006-05-10       Impact factor: 10.122

2.  Liver X receptor (LXR) regulates human adipocyte lipolysis.

Authors:  Britta M Stenson; Mikael Rydén; Nicolas Venteclef; Ingrid Dahlman; Annie M L Pettersson; Aline Mairal; Gaby Aström; Lennart Blomqvist; Victoria Wang; Johan W E Jocken; Karine Clément; Dominique Langin; Peter Arner; Jurga Laurencikiene
Journal:  J Biol Chem       Date:  2010-10-28       Impact factor: 5.157

Review 3.  The metabolic serine hydrolases and their functions in mammalian physiology and disease.

Authors:  Jonathan Z Long; Benjamin F Cravatt
Journal:  Chem Rev       Date:  2011-06-23       Impact factor: 60.622

4.  Characterization of Eicosanoids Produced by Adipocyte Lipolysis: IMPLICATION OF CYCLOOXYGENASE-2 IN ADIPOSE INFLAMMATION.

Authors:  Allison Gartung; Jiawei Zhao; Simon Chen; Emilio Mottillo; Garrett C VanHecke; Young-Hoon Ahn; Krishna Rao Maddipati; Andrey Sorokin; James Granneman; Menq-Jer Lee
Journal:  J Biol Chem       Date:  2016-05-31       Impact factor: 5.157

Review 5.  Chemical modulation of glycerolipid signaling and metabolic pathways.

Authors:  Sarah A Scott; Thomas P Mathews; Pavlina T Ivanova; Craig W Lindsley; H Alex Brown
Journal:  Biochim Biophys Acta       Date:  2014-01-15

6.  3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae.

Authors:  Astha Verma; Dawn M Wong; Rafique Islam; Fan Tong; Maryam Ghavami; James M Mutunga; Carla Slebodnick; Jianyong Li; Elisabet Viayna; Polo C-H Lam; Maxim M Totrov; Jeffrey R Bloomquist; Paul R Carlier
Journal:  Bioorg Med Chem       Date:  2015-01-22       Impact factor: 3.641

7.  Novel Pharmacological Probes Reveal ABHD5 as a Locus of Lipolysis Control in White and Brown Adipocytes.

Authors:  Elizabeth A Rondini; Ljiljana Mladenovic-Lucas; William R Roush; Geoff T Halvorsen; Alex E Green; James G Granneman
Journal:  J Pharmacol Exp Ther       Date:  2017-09-19       Impact factor: 4.030

8.  Atrial natriuretic peptide inhibits the production of adipokines and cytokines linked to inflammation and insulin resistance in human subcutaneous adipose tissue.

Authors:  C Moro; E Klimcakova; K Lolmède; M Berlan; M Lafontan; V Stich; A Bouloumié; J Galitzky; P Arner; D Langin
Journal:  Diabetologia       Date:  2007-02-23       Impact factor: 10.122

9.  Rat hormone sensitive lipase inhibition by cyclipostins and their analogs.

Authors:  Elena Vasilieva; Supratik Dutta; Raj K Malla; Benjamin P Martin; Christopher D Spilling; Cynthia M Dupureur
Journal:  Bioorg Med Chem       Date:  2015-01-22       Impact factor: 3.641

10.  Contribution of adipose triglyceride lipase and hormone-sensitive lipase to lipolysis in hMADS adipocytes.

Authors:  Véronic Bezaire; Aline Mairal; Carole Ribet; Corinne Lefort; Amandine Girousse; Johan Jocken; Jurga Laurencikiene; Rodica Anesia; Anne-Marie Rodriguez; Mikael Ryden; Britta M Stenson; Christian Dani; Gérard Ailhaud; Peter Arner; Dominique Langin
Journal:  J Biol Chem       Date:  2009-05-11       Impact factor: 5.157

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