Literature DB >> 15149659

Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases.

Paul F van Swieten1, Rene Maehr, Adrianus M C H van den Nieuwendijk, Benedikt M Kessler, Michael Reich, Chung-Sing Wong, Hubert Kalbacher, Michiel A Leeuwenburgh, Christoph Driessen, Gijsbert A van der Marel, Hidde L Ploegh, Herman S Overkleeft.   

Abstract

Quantification studies of complex protein mixtures have been restricted mainly to whole cell extracts. Here we describe the synthesis of two sets of isotope-coded activity-based probes that allow quantitative functional proteomics experiments on the cathepsins.

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Year:  2004        PMID: 15149659     DOI: 10.1016/j.bmcl.2004.04.046

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  3 in total

1.  A chemical proteomic probe for detecting dehydrogenases: catechol rhodanine.

Authors:  Xia Ge; Daniel S Sem
Journal:  Methods Mol Biol       Date:  2012

Review 2.  Activity-based probes as a tool for functional proteomic analysis of proteases.

Authors:  Marko Fonović; Matthew Bogyo
Journal:  Expert Rev Proteomics       Date:  2008-10       Impact factor: 3.940

3.  HIV-1-infected dendritic cells show 2 phases of gene expression changes, with lysosomal enzyme activity decreased during the second phase.

Authors:  Andrew N Harman; Marianne Kraus; Chris R Bye; Karen Byth; Stuart G Turville; Owen Tang; Sarah K Mercier; Najla Nasr; Josh L Stern; Barry Slobedman; Christoph Driessen; Anthony L Cunningham
Journal:  Blood       Date:  2009-05-12       Impact factor: 22.113

  3 in total

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