| Literature DB >> 15147810 |
A L Doadrio1, E M B Sousa, J C Doadrio, J Pérez Pariente, I Izquierdo-Barba, M Vallet-Regí.
Abstract
Mesoporous silica SBA-15 was prepared to evaluate its application as gentamicin drug delivery system. Two procedures were used to evaluate the delivery: calcined powder and disk conformed. The samples were charged with gentamicin sulphate and the experiments were carried out in vitro. No significant difference between powder and disk was observed in the tests. The release profiles exhibited a pronounced initial burst release effect of 60%, followed by a very slow release pattern. A new HPLC method was employed for calculated gentamicin amount in the delivery test. This method requires a small amount of sample, very advisable in these kinds of assays. Coyright 2004 Elsevier B.V.Entities:
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Year: 2004 PMID： 15147810 DOI： 10.1016/j.jconrel.2004.03.005
Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776