Literature DB >> 15146273

Impairment of male reproduction in adult rats exposed to hydroxyprogesterone caproate in utero.

T Pushpalatha1, P Ramachandra Reddy, P Sreenivasula Reddy.   

Abstract

Hydroxyprogesterone caproate is one of the most effective and widely used drugs for the treatment of uterine bleeding and threatened miscarriage in women. Hydroxyprogesterone caproate was administered to pregnant rats in order to assess the effect of intraperitoneal exposure to supranormal levels of hydroxyprogesterone caproate on the male reproductive potential in the first generation. The cauda epididymal sperm count and motility decreased significantly in rats exposed to hydroxyprogesterone caproate during embryonic development, when compared with control rats. The levels of serum testosterone decreased with an increase in follicle stimulating hormone and luteinizing hormone in adult rats exposed to hydroxyprogesterone caproate during the embryonic stage. It was suggested that the impairment of male reproductive performance could be mediated through the inhibition of testosterone production.

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Year:  2004        PMID： 15146273     DOI： 10.1007/s00114-004-0521-0

Source DB:  PubMed          Journal:  Naturwissenschaften        ISSN： 0028-1042


  11 in total

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Journal:  Cancer Res       Date:  1980-11       Impact factor: 12.701

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Authors:  R R Newbold; B C Bullock; J A McLachlan
Journal:  Cancer Res       Date:  1990-12-01       Impact factor: 12.701

6.  Effect of constant infusion of gonadotropin releasing hormone (GnRH) agonist buserelin and antagonist CDB 2085 A using osmotic minipumps on testicular function in adult male bonnet monkey (Macaca radiata).

Authors:  A J Rao; R Chakraborti; S G Kotagi; N Ravindranath
Journal:  Andrologia       Date:  1990 Nov-Dec       Impact factor: 2.775

Review 7.  Male reproductive health and environmental xenoestrogens.

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Journal:  Environ Health Perspect       Date:  1996-08       Impact factor: 9.031

8.  Evidence for a specific seminiferous tubular factor affecting follicle-stimulating hormone secretion in man.

Authors:  D H Van Thiel; R J Sherins; G H Myers; V T De Vita
Journal:  J Clin Invest       Date:  1972-04       Impact factor: 14.808

9.  Reduced fertility in female mice exposed transplacentally to diethylstilbestrol (DES).

Authors:  J A McLachlan; R R Newbold; H C Shah; M D Hogan; R L Dixon
Journal:  Fertil Steril       Date:  1982-09       Impact factor: 7.329

10.  Effect of prenatal exposure to hydroxyprogesterone on steroidogenic enzymes in male rats.

Authors:  T Pushpalatha; P Ramachandra Reddy; P Sreenivasula Reddy
Journal:  Naturwissenschaften       Date:  2002-12-20
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  3 in total

1.  Gestational exposure to hydroxyprogesterone caproate suppresses reproductive potential in male rats.

Authors:  T Pushpalatha; P Ramachandra Reddy; P Sreenivasula Reddy
Journal:  Naturwissenschaften       Date:  2005-10-25

2.  In utero exposure to 17α-hydroxyprogesterone caproate and risk of cancer in offspring.

Authors:  Caitlin C Murphy; Piera M Cirillo; Nickilou Y Krigbaum; Barbara A Cohn
Journal:  Am J Obstet Gynecol       Date:  2021-11-09       Impact factor: 10.693

3.  Gestational Exposure to Synthetic Steroid Hormones Impaired Sperm Quantity and Quality in Wistar Rats.

Authors:  Samy Ismail Ahmed; Aamir Magzoub; Mohammed Saeed Zayed Al-Ayed; Gamal Ali Attia; Basel A Abdel-Wahab; Masood M Khateeb; Asim M Abdalla; Heitham M Mohammed; Aymen N Eldeen A Elkareem; Ali Gadkarim A Salih
Journal:  Int J Endocrinol       Date:  2020-01-25       Impact factor: 3.257
  3 in total

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