Literature DB >> 16049688

Gestational exposure to hydroxyprogesterone caproate suppresses reproductive potential in male rats.

T Pushpalatha1, P Ramachandra Reddy, P Sreenivasula Reddy.   

Abstract

Hydroxyprogesterone caproate was administered to pregnant rats at a dose level of 10 and 25 mg/kg body weight on 1st, 7th and 14th gestational day and the male pups (F1 generation) were allowed to grow for 90 days. The effect of gestational exposure to hydroxyprogesterone caproate on fertility was assessed by breeding F1 male rats with control female rats besides analyzing sperm quality and quantity in F1 male rats. The number of implantation sites and viable fetuses was significantly reduced in females mated with F1 males that were exposed to hydroxyprogesterone caproate during embryonic development. The decrease in sperm function was associated with a decrease in sperm motility, sperm viability and sperm count in F1 rats. The study clearly indicates that in utero exposure to hydroxyprogesterone caproate affects fertility in male rats.

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Year:  2005        PMID： 16049688     DOI： 10.1007/s00114-005-0005-x

Source DB:  PubMed          Journal:  Naturwissenschaften        ISSN： 0028-1042


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Authors:  T Pushpalatha; P Ramachandra Reddy; P Sreenivasula Reddy
Journal:  Naturwissenschaften       Date:  2002-12-20

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  3 in total

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2.  Critical appraisal of the efficacy, safety, and patient acceptability of hydroxyprogesterone caproate injection to reduce the risk of preterm birth.

Authors:  Alex C Vidaeff; Michael A Belfort
Journal:  Patient Prefer Adherence       Date:  2013-07-11       Impact factor: 2.711

3.  Gestational Exposure to Synthetic Steroid Hormones Impaired Sperm Quantity and Quality in Wistar Rats.

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Journal:  Int J Endocrinol       Date:  2020-01-25       Impact factor: 3.257
  3 in total

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