| Literature DB >> 15145526 |
Uwe Zimmermann1, Stefan Balabanov, Jürgen Giebel, Steffen Teller, Heike Junker, Dieter Schmoll, Chris Protzel, Christian Scharf, Britta Kleist, Reinhard Walther.
Abstract
The proteome of renal cell carcinoma and non-neoplastic kidney tissue was analysed from 12 patients by two-dimensional polyacrylamide gel electrophoresis to search for differentially expressed proteins in the tumour. Annexin IV was identified to be up-regulated in tumour cells. These patients and further 11 were characterized by RT-PCR. We found an increased amount of annexin IV mRNA. Immunohistochemical analysis revealed an altered localization of annexin IV in tumour cells. Additionally we demonstrate that over-expressed annexin IV promotes cell migration in a carcinoma model system. From these results above it seems possible that annexin IV plays an important role in the morphological diversification and dissemination of the clear cell renal cell carcinoma.Entities:
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Year: 2004 PMID： 15145526 DOI： 10.1016/j.canlet.2003.12.002
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679