Literature DB >> 15143449

[Aminoglycoside- and cisplatin-ototoxicity: from basic science to clinics].

J Lautermann1, N Dehne, J Schacht, K Jahnke.   

Abstract

Gentamicin and cisplatin are clinically widely used pharmacological agents which may induce irreversible hearing loss as a side effect. Concerning the pathomechanisms of ototoxicity as well as preventive strategies there are similarities but also some differences. In this review we focus on the role of reactive oxygen species, the antioxidant system, cellular iron and calcium as well as nitric oxide and neurotrophins on gentamicin- and cisplatin-ototoxicity. Furthermore we deal with apoptotic and necrotic cell death as well as the role of mitochondria in these cell injury processes.

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Year:  2004        PMID： 15143449     DOI： 10.1055/s-2004-814280

Source DB:  PubMed          Journal:  Laryngorhinootologie        ISSN： 0935-8943            Impact factor:   1.057


  9 in total

1.  Therapy of hearing disorders - conservative procedures.

Authors:  Stefan Plontke
Journal:  GMS Curr Top Otorhinolaryngol Head Neck Surg       Date:  2005-09-28

2.  Oriented collagen as a potential cochlear implant electrode surface coating to achieve directed neurite outgrowth.

Authors:  Stefan Volkenstein; John E Kirkwood; Edwina Lai; Stefan Dazert; Gerald G Fuller; Stefan Heller
Journal:  Eur Arch Otorhinolaryngol       Date:  2011-09-28       Impact factor: 2.503

3.  Influence of bone morphogenetic protein-2 on spiral ganglion neurite growth in vitro.

Authors:  Stefan Volkenstein; D Brors; S Hansen; A Minovi; M Laub; H P Jennissen; S Dazert; A Neumann
Journal:  Eur Arch Otorhinolaryngol       Date:  2009-03-06       Impact factor: 2.503

4.  Simvastatin protects auditory hair cells from gentamicin-induced toxicity and activates Akt signaling in vitro.

Authors:  Yves Brand; Cristian Setz; Soledad Levano; Alwin Listyo; Eduardo Chavez; Kwang Pak; Michael Sung; Vesna Radojevic; Allen F Ryan; Daniel Bodmer
Journal:  BMC Neurosci       Date:  2011-11-14       Impact factor: 3.288

5.  A novel mammalian expression system derived from components coordinating nicotine degradation in arthrobacter nicotinovorans pAO1.

Authors:  Laetitia Malphettes; Cornelia C Weber; Marie Daoud El-Baba; Ronald G Schoenmakers; Dominique Aubel; Wilfried Weber; Martin Fussenegger
Journal:  Nucleic Acids Res       Date:  2005-07-07       Impact factor: 16.971

6.  Role of somatostatin receptor-2 in gentamicin-induced auditory hair cell loss in the Mammalian inner ear.

Authors:  Yves Brand; Vesna Radojevic; Michael Sung; Eric Wei; Cristian Setz; Andrea Glutz; Katharina Leitmeyer; Daniel Bodmer
Journal:  PLoS One       Date:  2014-09-30       Impact factor: 3.240

7.  A synthetic free fatty acid-regulated transgene switch in mammalian cells and mice.

Authors:  Ying Liu; Ghislaine Charpin-El Hamri; Haifeng Ye; Martin Fussenegger
Journal:  Nucleic Acids Res       Date:  2018-10-12       Impact factor: 16.971

8.  An engineered L-arginine sensor of Chlamydia pneumoniae enables arginine-adjustable transcription control in mammalian cells and mice.

Authors:  Shizuka Hartenbach; Marie Daoud-El Baba; Wilfried Weber; Martin Fussenegger
Journal:  Nucleic Acids Res       Date:  2007-10-18       Impact factor: 16.971

9.  Inhibition of mTOR by Rapamycin Results in Auditory Hair Cell Damage and Decreased Spiral Ganglion Neuron Outgrowth and Neurite Formation In Vitro.

Authors:  Katharina Leitmeyer; Andrea Glutz; Vesna Radojevic; Cristian Setz; Nathan Huerzeler; Helen Bumann; Daniel Bodmer; Yves Brand
Journal:  Biomed Res Int       Date:  2015-03-31       Impact factor: 3.411
  9 in total

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