Literature DB >> 15138192

Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines, and T-cell proliferation.

Teresa Krakauer1.   

Abstract

Proinflammatory cytokines mediate the toxic effect of superantigenic staphylococcal exotoxins (SE). A pan-caspase inhibitor suppressed SE-stimulated T-cell proliferation and the production of cytokines and chemokines by human peripheral blood mononuclear cells. These data suggest that caspase inhibitors may represent a novel therapeutic modality for treating SE-induced toxic shock.

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Year:  2004        PMID： 15138192      PMCID： PMC404582          DOI： 10.1128/CDLI.11.3.621-624.2004

Source DB:  PubMed          Journal:  Clin Diagn Lab Immunol        ISSN： 1071-412X


  19 in total

1.  Attenuation of bleomycin-induced pneumopathy in mice by a caspase inhibitor.

Authors:  K Kuwano; R Kunitake; T Maeyama; N Hagimoto; M Kawasaki; T Matsuba; M Yoshimi; I Inoshima; K Yoshida; N Hara
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2001-02       Impact factor: 5.464

2.  Caspase-mediated calcineurin activation contributes to IL-2 release during T cell activation.

Authors:  N Mukerjee; K M McGinnis; M E Gnegy; K K Wang
Journal:  Biochem Biophys Res Commun       Date:  2001-08-03       Impact factor: 3.575

Review 3.  Caspase activation without death.

Authors:  A Zeuner; A Eramo; C Peschle; R De Maria
Journal:  Cell Death Differ       Date:  1999-11       Impact factor: 15.828

Review 4.  Regulation of helper T cell responses to staphylococcal superantigens.

Authors:  S B Cameron; M C Nawijn; W W Kum; H F Savelkoul; A W Chow
Journal:  Eur Cytokine Netw       Date:  2001 Apr-Jun       Impact factor: 2.737

5.  Substrate specificities of caspase family proteases.

Authors:  R V Talanian; C Quinlan; S Trautz; M C Hackett; J A Mankovich; D Banach; T Ghayur; K D Brady; W W Wong
Journal:  J Biol Chem       Date:  1997-04-11       Impact factor: 5.157

6.  Induction of CC chemokines in human peripheral blood mononuclear cells by staphylococcal exotoxins and its prevention by pentoxifylline.

Authors:  T Krakauer
Journal:  J Leukoc Biol       Date:  1999-07       Impact factor: 4.962

Review 7.  Caspases: the executioners of apoptosis.

Authors:  G M Cohen
Journal:  Biochem J       Date:  1997-08-15       Impact factor: 3.857

8.  Inhibition of human caspases by peptide-based and macromolecular inhibitors.

Authors:  M Garcia-Calvo; E P Peterson; B Leiting; R Ruel; D W Nicholson; N A Thornberry
Journal:  J Biol Chem       Date:  1998-12-04       Impact factor: 5.157

9.  Caspase activation is required for T cell proliferation.

Authors:  N J Kennedy; T Kataoka; J Tschopp; R C Budd
Journal:  J Exp Med       Date:  1999-12-20       Impact factor: 14.307

10.  Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells.

Authors:  A Alam; L Y Cohen; S Aouad; R P Sékaly
Journal:  J Exp Med       Date:  1999-12-20       Impact factor: 14.307
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  6 in total

1.  Bacillus anthracis edema toxin inhibits Staphylococcus aureus enterotoxin B effects in vitro: a potential protein therapeutic?

Authors:  Teresa Krakauer; Stephen F Little; Bradley G Stiles
Journal:  Infect Immun       Date:  2005-10       Impact factor: 3.441

2.  Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition.

Authors:  Staci D Bilbo; Joseph C Biedenkapp; Andre Der-Avakian; Linda R Watkins; Jerry W Rudy; Steven F Maier
Journal:  J Neurosci       Date:  2005-08-31       Impact factor: 6.167

Review 3.  Therapeutic down-modulators of staphylococcal superantigen-induced inflammation and toxic shock.

Authors:  Teresa Krakauer
Journal:  Toxins (Basel)       Date:  2010-07-29       Impact factor: 4.546

Review 4.  PI3K/Akt/mTOR, a pathway less recognized for staphylococcal superantigen-induced toxicity.

Authors:  Teresa Krakauer
Journal:  Toxins (Basel)       Date:  2012-11-15       Impact factor: 4.546

Review 5.  Update on staphylococcal superantigen-induced signaling pathways and therapeutic interventions.

Authors:  Teresa Krakauer
Journal:  Toxins (Basel)       Date:  2013-09-24       Impact factor: 4.546

6.  TIFA, an inflammatory signaling adaptor, is tumor suppressive for liver cancer.

Authors:  W Shen; A Chang; J Wang; W Zhou; R Gao; J Li; Y Xu; X Luo; R Xiang; N Luo; D G Stupack
Journal:  Oncogenesis       Date:  2015-10-26       Impact factor: 7.485
  6 in total

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