| Literature DB >> 15137773 |
Anna M Piatek1, Yannick J Bomble, Sheryl L Wiskur, Eric V Anslyn.
Abstract
The mathematics for modeling indicator-displacement assay isotherms is presented and contrasted to the classical host-guest binding isotherm. It is shown that the signal response can be tuned to occur closer to 1 equiv of guest relative to a standard binding algorithm. This delay in response leads to a better triggering protocol for threshold detection schemes. The determination of malate in Pinot Noir must was calculated using this new mathematical model, which demonstrates how a color change can be tuned to occur near a desired concentration of analyte.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15137773 DOI： 10.1021/ja040006e
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419