Literature DB >> 15136700

Alzheimer disease risk associated with APOE4 is modified by STH gene polymorphism.

D Seripa1, M G Matera, R P D'Andrea, C Gravina, C Masullo, A Daniele, A Bizzarro, M Rinaldi, P Antuono, D R Wekstein, G Dal Forno, V M Fazio.   

Abstract

The association of the STH gene polymorphism with Alzheimer disease (AD) is debated. In the analysis of two genetically and diagnostically distinct groups of Alzheimer patients from the USA and Italy, the authors did not find an association with the STH polymorphism. However, the APOE-4-associated risk of AD greatly increased if the STH-G allele was also present. The STH-G allele appears to be a risk modifier for AD.

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Year:  2004        PMID: 15136700     DOI: 10.1212/01.wnl.0000125693.59817.31

Source DB:  PubMed          Journal:  Neurology        ISSN: 0028-3878            Impact factor:   9.910


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