| Literature DB >> 15135063 |
Shuan Shian Huang1, Sandra M Leal, Chun-Lin Chen, I-Hua Liu, Jung San Huang.
Abstract
In Mv1Lu cells, insulin partially reverses transforming growth factor-beta1 (TGF-beta1) growth inhibition in the presence of alpha5beta1 integrin antagonists. TGF-beta1 appears to induce phosphorylation of IRS-2 in these cells; this is inhibited by a TGF-beta antagonist known to reverse TGF-beta growth inhibition. Stable transfection of 32D myeloid cells (which lack endogenous IRS proteins and are insensitive to growth inhibition by TGF-beta1) with IRS-1 or IRS-2 cDNA confers sensitivity to growth inhibition by TGF-beta1; this IRS-mediated growth inhibition can be partially reversed by insulin in 32D cells stably expressing IRS-2 and the insulin receptor (IR). These results suggest that growth inhibition by TGF-beta1 involves IRS proteins.Entities:
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Year: 2004 PMID： 15135063 DOI： 10.1016/j.febslet.2004.03.082
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124