| Literature DB >> 15134542 |
S Peyrottes1, D Egron, I Lefebvre, G Gosselin, J-L Imbach, C Périgaud.
Abstract
This review depicts in vitro and in vivo results obtained with nucleotide prodrugs (pronucleotides) bearing S-acyl-2-thioethyl (SATE) groups as esterase-labile phosphate protections. New developments are illustrated by the design of mononucleoside mixed phosphoester derivatives leading to the selective intracellular delivery of the corresponding 5'-mononucleotide through two different enzyme-mediated activation steps.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15134542 DOI： 10.2174/1389557043404007
Source DB: PubMed Journal: Mini Rev Med Chem ISSN： 1389-5575 Impact factor: 3.862