Literature DB >> 15134282

Inhibition of glycerol-3-phosphate acyltransferase as a potential treatment for insulin resistance and type 2 diabetes.

Eva Rupp Thuresson1.   

Abstract

This review focuses on the potential of glycerol-3-phosphate acyltransferase (GPAT) inhibition as a strategy to treat insulin resistance, one of the characteristics of obesity and type 2 diabetes. Inhibition of GPAT, which catalyzes the first and committed step in triacylglyceride synthesis, has the potential to reduce accumulation of ectopic fat in insulin-sensitive organs such as the liver and skeletal muscle. Such an accumulation of fat has been shown to be correlated with insulin resistance. Thus, its reduction by pharmacological treatment is an attractive strategy to treat type 2 diabetes. Potential methods to identify inhibitors for acyltransferases suitable for treatment of human diseases are described.

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Year:  2004        PMID： 15134282

Source DB:  PubMed          Journal:  Curr Opin Investig Drugs        ISSN： 1472-4472


  9 in total

1.  Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity.

Authors:  Francis P Kuhajda; Susan Aja; Yajun Tu; Wan Fang Han; Susan M Medghalchi; Rajaa El Meskini; Leslie E Landree; Jonathan M Peterson; Khadija Daniels; Kody Wong; Edward A Wydysh; Craig A Townsend; Gabriele V Ronnett
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2011-04-13       Impact factor: 3.619

2.  Molecular cloning of a murine glycerol-3-phosphate acyltransferase-like protein 1 (xGPAT1).

Authors:  Nagakatsu Harada; Sayuri Hara; Masaki Yoshida; Tomoe Zenitani; Kazuaki Mawatari; Masayuki Nakano; Akira Takahashi; Toshio Hosaka; Katsuhiko Yoshimoto; Yutaka Nakaya
Journal:  Mol Cell Biochem       Date:  2006-09-30       Impact factor: 3.396

3.  Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis.

Authors:  Jingsong Cao; Jian-Liang Li; Dongmei Li; James F Tobin; Ruth E Gimeno
Journal:  Proc Natl Acad Sci U S A       Date:  2006-12-14       Impact factor: 11.205

4.  Sustained rise in triacylglycerol synthesis and increased epididymal fat mass when rats cease voluntary wheel running.

Authors:  David S Kump; Frank W Booth
Journal:  J Physiol       Date:  2005-03-17       Impact factor: 5.182

5.  Aralia cordata inhibits triacylglycerol biosynthesis in HepG2 cells.

Authors:  Mun Ock Kim; Sun Hwa Lee; Jee Hee Seo; Il Soon Kim; Ah Reum Han; Dong Oh Moon; Sungchan Cho; Long Cui; Jungwoo Kim; Hyun Sun Lee
Journal:  J Med Food       Date:  2013-11-27       Impact factor: 2.786

6.  The presence of distal and proximal promoters for rat mitochondrial glycerol-3-phosphate acyltransferase.

Authors:  Kawalpreet K Aneja; Prajna Guha; Rasheda Y Shilpi; Sanjoy Chakraborty; Laura M Schramm; Dipak Haldar
Journal:  Arch Biochem Biophys       Date:  2007-11-04       Impact factor: 4.013

7.  Different gene expression profiles in subcutaneous & visceral adipose tissues from Mexican patients with obesity.

Authors:  María D Ronquillo; Alla Mellnyk; Noemí Cárdenas-Rodríguez; Emmanuel Martínez; David A Comoto; Liliana Carmona-Aparicio; Norma E Herrera; Eleazar Lara; Armando Pereyra; Esaú Floriano-Sánchez
Journal:  Indian J Med Res       Date:  2019-05       Impact factor: 2.375

8.  Standardized rice bran extract improves hepatic steatosis in HepG2 cells and ovariectomized rats.

Authors:  Dong Wook Lim; Hyejin Jeon; Minji Kim; Minseok Yoon; Jonghoon Jung; Sangoh Kwon; Suengmok Cho; Min Young Um
Journal:  Nutr Res Pract       Date:  2020-07-02       Impact factor: 1.926

Review 9.  The Role of Ceramides in Insulin Resistance.

Authors:  Emilia Sokolowska; Agnieszka Blachnio-Zabielska
Journal:  Front Endocrinol (Lausanne)       Date:  2019-08-21       Impact factor: 5.555
  9 in total

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