Literature DB >> 15128234

Efficient synthesis of phosphorylated prodrugs with bis(POM)-phosphoryl chloride.

Yousang Hwang1, Philip A Cole.   

Abstract

An efficient method for the synthesis of phosphorylated prodrugs is described. The preparation of various bis-pivaloyloxymethyl (POM) phosphate triesters was accomplished in moderate to good yields with the use of bis(POM) phosphoryl chloride under mild conditions.

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Year:  2004        PMID: 15128234     DOI: 10.1021/ol049714v

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  5 in total

1.  Enzymatic and cellular study of a serotonin N-acetyltransferase phosphopantetheine-based prodrug.

Authors:  Yousang Hwang; Surajit Ganguly; Anthony K Ho; David C Klein; Philip A Cole
Journal:  Bioorg Med Chem       Date:  2006-12-13       Impact factor: 3.641

Review 2.  Synthesis of nucleoside phosphate and phosphonate prodrugs.

Authors:  Ugo Pradere; Ethel C Garnier-Amblard; Steven J Coats; Franck Amblard; Raymond F Schinazi
Journal:  Chem Rev       Date:  2014-08-21       Impact factor: 60.622

3.  De novo discovery of serotonin N-acetyltransferase inhibitors.

Authors:  Lawrence M Szewczuk; S Adrian Saldanha; Surajit Ganguly; Erin M Bowers; Margarita Javoroncov; Balasubramanyam Karanam; Jeffrey C Culhane; Marc A Holbert; David C Klein; Ruben Abagyan; Philip A Cole
Journal:  J Med Chem       Date:  2007-10-09       Impact factor: 7.446

4.  A phosphorylated prodrug for the inhibition of Pin1.

Authors:  Song Zhao; Felicia A Etzkorn
Journal:  Bioorg Med Chem Lett       Date:  2007-09-26       Impact factor: 2.823

5.  Synthesis and biological evaluation of phosphate prodrugs of 4-phospho-D-erythronohydroxamic acid, an inhibitor of 6-phosphogluconate dehydrogenase.

Authors:  Gian Filippo Ruda; Vincent P Alibu; Christos Mitsos; Olivier Bidet; Marcel Kaiser; Reto Brun; Michael P Barrett; Ian H Gilbert
Journal:  ChemMedChem       Date:  2007-08       Impact factor: 3.466

  5 in total

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