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Literature DB >> 15127006

Progressive beta cell failure in type 2 diabetes mellitus of youth.

Abstract

The pathophysiology of type 2 diabetes mellitus (T2DM) involves insulin resistance and insulin deficiency. We report the progression in insulin sensitivity and secretion over a 6-year period in an adolescent with T2DM. This report further demonstrates that the earliest abnormality in youth T2DM is insulin resistance followed by progressive beta-cell failure.

Entities: Disease Gene

Mesh：

Year: 2004 PMID： 15127006 DOI： 10.1016/j.jpeds.2003.12.045

Source DB: PubMed Journal: J Pediatr ISSN： 0022-3476 Impact factor: 4.406

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Cited

28 in total

1. Clinical trials in youth with type 2 diabetes.

Authors: Julie Anne L Gemmill; Rebecca J Brown; Radha Nandagopal; Luisa M Rodriguez; Kristina I Rother
Journal: Pediatr Diabetes Date: 2011-02 Impact factor: 4.866

Review 2. Early onset type 2 diabetes: risk factors, clinical impact and management.

Authors: Emma Wilmot; Iskandar Idris
Journal: Ther Adv Chronic Dis Date: 2014-11 Impact factor: 5.091

Review 3. Insulin resistance in type 2 diabetic youth.

Authors: Kara Mizokami-Stout; Melanie Cree-Green; Kristen J Nadeau
Journal: Curr Opin Endocrinol Diabetes Obes Date: 2012-08 Impact factor: 3.243

Review 4. Type 2 diabetes mellitus in pediatrics: a new challenge.

Authors: Michelle Van Name; Nicola Santoro
Journal: World J Pediatr Date: 2013-11-14 Impact factor: 2.764

5. Clinical Features and Microvascular Complications Risk Factors of Early-onset Type 2 Diabetes Mellitus.

Authors: Jia-Xin Huang; Yun-Fei Liao; Yu-Ming Li
Journal: Curr Med Sci Date: 2019-10-14

6. Trajectories of changes in glucose tolerance in a multiethnic cohort of obese youths: an observational prospective analysis.

Authors: Alfonso Galderisi; Cosimo Giannini; Ram Weiss; Grace Kim; Veronika Shabanova; Nicola Santoro; Bridget Pierpont; Mary Savoye; Sonia Caprio
Journal: Lancet Child Adolesc Health Date: 2018-08-24

Progressive beta cell failure in type 2 diabetes mellitus of youth.

1. Clinical trials in youth with type 2 diabetes.

Review 2. Early onset type 2 diabetes: risk factors, clinical impact and management.

Review 3. Insulin resistance in type 2 diabetic youth.

Review 4. Type 2 diabetes mellitus in pediatrics: a new challenge.

5. Clinical Features and Microvascular Complications Risk Factors of Early-onset Type 2 Diabetes Mellitus.

6. Trajectories of changes in glucose tolerance in a multiethnic cohort of obese youths: an observational prospective analysis.

7. Childhood obesity and type 2 diabetes: the frightening epidemic.

8. β-cell dysfunction in adolescents and adults with newly diagnosed type 2 diabetes mellitus.

9. Reversal of type 2 diabetes in youth who adhere to a very-low-energy diet: a pilot study.

10. Progressive deterioration of β-cell function in obese youth with type 2 diabetes.