BACKGROUND: The increased prevalence of childhood obesity in the last few years has been accompanied by the increase in prevalence of type 2 diabetes in pediatrics. In this paper, we will review the risk factors and the pathogenic determinants leading to type 2 diabetes in youth. DATA SOURCES: We searched on PubMed with the key words: obesity, type 2 diabetes, children, adolescents, youth, non-alcoholic fatty liver disease, genes and selected those publications written in English that we judged to be relevant to the topic of the review. RESULTS: Based on the data present in the literature, we reviewed the following three topics: 1) the role of ectopic fat deposition, in particular of fatty liver, in the pathogenesis of pediatric type 2 diabetes; 2) the progression to type 2 diabetes in pediatrics and how it differs from adults, and 3) current theraputic options. CONCLUSION: Type 2 diabetes in youth is a complex disease, creating new challenges in treatment and prevention.
BACKGROUND: The increased prevalence of childhood obesity in the last few years has been accompanied by the increase in prevalence of type 2 diabetes in pediatrics. In this paper, we will review the risk factors and the pathogenic determinants leading to type 2 diabetes in youth. DATA SOURCES: We searched on PubMed with the key words: obesity, type 2 diabetes, children, adolescents, youth, non-alcoholic fatty liver disease, genes and selected those publications written in English that we judged to be relevant to the topic of the review. RESULTS: Based on the data present in the literature, we reviewed the following three topics: 1) the role of ectopic fat deposition, in particular of fatty liver, in the pathogenesis of pediatric type 2 diabetes; 2) the progression to type 2 diabetes in pediatrics and how it differs from adults, and 3) current theraputic options. CONCLUSION: Type 2 diabetes in youth is a complex disease, creating new challenges in treatment and prevention.
Authors: C L Rohlfing; R R Little; H M Wiedmeyer; J D England; R Madsen; M I Harris; K M Flegal; M S Eberhardt; D E Goldstein Journal: Diabetes Care Date: 2000-02 Impact factor: 19.112
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Authors: Johan Staaf; Viktor Labmayr; Katharina Paulmichl; Hannes Manell; Jing Cen; Iris Ciba; Marie Dahlbom; Kirsten Roomp; Christian-Heinz Anderwald; Matthias Meissnitzer; Reinhard Schneider; Anders Forslund; Kurt Widhalm; Jonas Bergquist; Håkan Ahlström; Peter Bergsten; Daniel Weghuber; Joel Kullberg Journal: Pancreas Date: 2017-03 Impact factor: 3.327