| Literature DB >> 15125967 |
William J Pitts1, Wayne Vaccaro, Tram Huynh, Katerina Leftheris, Jacques Y Roberge, Joseph Barbosa, Junqing Guo, Baerbel Brown, Andrew Watson, Karen Donaldson, Gary C Starling, Peter A Kiener, Michael A Poss, John H Dodd, Joel C Barrish.
Abstract
A series of purine based inhibitors of PDE7 has been derived from screening lead 1a. The synthesis, structure-activity relationships (SAR), and selectivity against several other PDE family members are described.Entities:
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Year: 2004 PMID： 15125967 DOI： 10.1016/j.bmcl.2004.03.021
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823